monkeybones
Well-Known Member
You know, ever since i started growing and using this site, I would always read about how sativas are much better of a mind high, and indicas would give you a heavy body high and couch-lock
so, like many other people, i ordered a sativa dominant strain to start off with and never really even tried a plain indica
and like some others, to me pot is just how i feel normal after years of consumption. it kind of lost the ability to make me tremble with joy or anticipation.
these days, i just smoke 8-12 bowls over a 16 hour time period (straight up sativa, of course), and live a pretty normal life. the one thing weed does for me 100% of the time now is induce lethargy
so i've been reading on wikipedia and i'm interested in whether my CB1 receptor has gone neglected for a while.
Tetrahydrocannabivarin
Tetrahydrocannabivarin (THCV, THV) is a homologue of tetrahydrocannabinol (THC) having a propyl (3-carbon) side chain. This terpeno-phenolic compound is found naturally in Cannabis, sometimes in significant amounts. The psychoactive effects of THCV in Cannabis preparations are not well characterized.
Plants with elevated levels of propyl cannabinoids (including THCV) have been found in populations of Cannabis sativa L. ssp. indica (= Cannabis indica Lam.) from China, India, Nepal, Thailand, Afghanistan, and Pakistan, as well as southern and western Africa. THCV levels up to 53.7% of total cannabinoids have been reported. [1] [2]
THCV has been shown to be a CB1 receptor antagonist, i.e. it blocks the effects of THC.[3]
References
[1] Turner, C.E., Hadley, K.W., and Fetterman, P. 1973. Constituents of Cannabis Sativa L., VI: Propyl Homologues in Samples of Known Geographical Origin. J. Pharm. Sci. 62(10):1739-1741
[2] Hillig, Karl W. and Paul G. Mahlberg. 2004. A chemotaxonomic analysis of cannabinoid variation in Cannabis (Cannabaceae). American Journal of Botany 91(6): 966-975.
[3] Pertwee RG, Thomas A, Stevenson LA, et al. 2007. The psychoactive plant cannabinoid, Δ9-tetrahydrocannabinol, is antagonized by Δ8- and Δ9-tetrahydrocannabivarin in mice in vivo. Br. J. Pharmacol. 150(5): 586–94.
so, like many other people, i ordered a sativa dominant strain to start off with and never really even tried a plain indica
and like some others, to me pot is just how i feel normal after years of consumption. it kind of lost the ability to make me tremble with joy or anticipation.
these days, i just smoke 8-12 bowls over a 16 hour time period (straight up sativa, of course), and live a pretty normal life. the one thing weed does for me 100% of the time now is induce lethargy
so i've been reading on wikipedia and i'm interested in whether my CB1 receptor has gone neglected for a while.
Tetrahydrocannabivarin
Tetrahydrocannabivarin (THCV, THV) is a homologue of tetrahydrocannabinol (THC) having a propyl (3-carbon) side chain. This terpeno-phenolic compound is found naturally in Cannabis, sometimes in significant amounts. The psychoactive effects of THCV in Cannabis preparations are not well characterized.
Plants with elevated levels of propyl cannabinoids (including THCV) have been found in populations of Cannabis sativa L. ssp. indica (= Cannabis indica Lam.) from China, India, Nepal, Thailand, Afghanistan, and Pakistan, as well as southern and western Africa. THCV levels up to 53.7% of total cannabinoids have been reported. [1] [2]
THCV has been shown to be a CB1 receptor antagonist, i.e. it blocks the effects of THC.[3]
References
[1] Turner, C.E., Hadley, K.W., and Fetterman, P. 1973. Constituents of Cannabis Sativa L., VI: Propyl Homologues in Samples of Known Geographical Origin. J. Pharm. Sci. 62(10):1739-1741
[2] Hillig, Karl W. and Paul G. Mahlberg. 2004. A chemotaxonomic analysis of cannabinoid variation in Cannabis (Cannabaceae). American Journal of Botany 91(6): 966-975.
[3] Pertwee RG, Thomas A, Stevenson LA, et al. 2007. The psychoactive plant cannabinoid, Δ9-tetrahydrocannabinol, is antagonized by Δ8- and Δ9-tetrahydrocannabivarin in mice in vivo. Br. J. Pharmacol. 150(5): 586–94.
discuss
