Ace Yonder
Well-Known Member
Actually someone else claimed it was complete BS, I just responded with evidence as to why it might be, and left MY overriding conclusion as "More research is needed, until then I am unconvinced", which is why I chose to bolden the sections of my quoted material that said just that, and people still did disagree with me. And I read the quote you posted from the article, it doesn't really offer an actual explanation other than to just formalize and specify their original assessment based on their one patient. Also I don't know if you followed the rabbit hole at all but the source(s) they quote as having "hypothesized that the principal psychoactive constituent of the cannabis plant, Delta-9-tetrahydrocannabinol (THC) is the causative agent in CHS [3]. THC has been shown to cause delayed gastric emptying and thermoregulatory disturbances via action on the cannabinoid receptor type 1 (CB1) in the enteric plexus and central nervous system, respectively [5]" is just from the OTHER study of 98 patients, a study which includes the following line in discussing their results and their conclusion. "[of the 98 patients] Follow-up was available in only 10 patients (10%). Of those 10, 7 (70%) stopped using cannabis and 6 of these 7 (86%) noted complete resolution of their symptoms." The fact that that study is the source quoted as evidence for the quote you posted means their "hypothesis" about THC and CB1 detectors is again not based on actual chemistry and physiology, but is just their best guess as to what MAY (May also happens to be the word they use) cause it. This is not the kind of evidence I will accept as proof.Well if you were a little bit more opened minded, perhaps you'd spend a few minutes doing a google search:
"It has been hypothesized that the principal psychoactive constituent of the cannabis plant, Delta-9-tetrahydrocannabinol (THC) is the causative agent in CHS [3]. THC has been shown to cause delayed gastric emptying and thermoregulatory disturbances via action on the cannabinoid receptor type 1 (CB1) in the enteric plexus and central nervous system, respectively [5]. Chronic stimulation of the CB1 receptors may result in the development of the gastrointestinal and thermodysregulation symptoms in sensitive patients [6], though more research needs to be conducted to further elucidate what factors may predispose certain patients."
Just because you don't have symptoms, doesn't mean others don't. If you'd just said, "more research would be helpful", and left it at that, nobody would disagree with you. To claim the diagnose is complete B.S. is about as useful as ... well you know what.
Cheers.