It's all about what works for you. I choose to turn over a higher quantity of seeds in a quicker time, using smaller pots (6 gallon) and shorter veg times. I find that it works for my budget, saves soil, and maximizes my time and space utility.
For others, spending 5 months growing 4 plants that yield a total of 10 ounces makes much more sense. For me, it makes more sense to grow 16 plants in the same amount of time that yield 15-30 grams each...
Agreed on this one - completely... veg time, light type and size (if indoors, wattage.. outdoors is pretty obvious), pot sizes, what nutes you're running, etc. Any answer given would also assume that the grow has gone perfectly, with nothing causing the slightest issue - a set of perfect grow conditions vs the strain, more specifically.