Hey BWG I think I know you from another forum a few years ago...
Ya man I have found it makes it very hard for the oil to firm up if you are trying to make a firm wax/honeycomb/moonrock etc..
And more of a bitter taste to the smoke. It stays in your mouth and on your tongue like a tin metallic kind of flavor.
That is my findings with it from my own crop that I had used neem on. I ran the oil at the same time as running non neem sprayed flowers of the same strain etc. So the affect was very obvious. The neem sprayed flower extract also had an oily film on it even as it tried to harden up during vac purge. The same butane brand was used for both batches.
Not sure about using the neem pre flowering having the same affect. I would imagine it may not but not sure. I don't know if the plant is absorbing it into it's system and then later having an affect on the flowers tastes and oil production.