I use 2 different brands. Protek gets applied when ever I use straight water and Rhino skin when mixing nutrients. The protek will curdle when added, I have found that mixing it first or last, if you let sit it will separate. The Rhino has been formulated not to do this so it can be mixed however you like and it will not react no matter how long it sits. Being hydro and especially Rockwool, silica is very important for root binding and stem development.