Two months old. they must be hugh. hell my two month old plant started from seed was over two feet already. But as far as your question, It is a weed meaning it is pretty hard to kill. As far as saving it, you can always save it. My main concern would be all the stress placed on the little plant could have made it want to become a male but you never know until you try. As far as transplanting, hell you can do it when ever you want but it is best to wait until it has a good root structure, Pics would help a whole lot.
IT IS NOT A WEED....
Cannabis (
Cán-na-bis; English pronunciation:
/ˈkænəbɪs/) is a
genus of
flowering plants that includes three putative species,
Cannabis sativa,
[1] Cannabis indica,
[1] and
Cannabis ruderalis. These three
taxa are
indigenous to
Central Asia, and
South Asia.
[2] Cannabis has long been used for fibre (
hemp), for seed and seed oils, for
medicinal purposes, and as a
recreational drug. Industrial
hemp products are made from
Cannabis plants selected to produce an abundance of fiber. To satisfy the
UN Narcotics Convention, some hemp strains have been developed which contain minimal levels of
THC (Δ9- tetrahydrocannabinol), one of the
psychoactive molecules that produces the "high" associated with
marijuana. The psychoactive product consists of dried flowers of plants selectively bred to produce high levels of THC and other psychoactive chemicals. Various extracts including
hashish and
hash oil are also produced from the plant.
[3]
Etymology
Main article:
Cannabis (etymology)
The word
cannabis is from
Greek κάνναβις (
kánnabis) (see
Latin cannabis),
[4] which was originally
Scythian or
Thracian.
[5] It is related to the
Persian kanab, the English
canvas and possibly even to the English
hemp (Old English hænep).
[5] In modern
Hebrew,
קַנַּבּוֹס [qanːaˈboːs] is used but
מעלה עשן [maːaˈ:le aˈ:shaa:n] (smoke bringer) is the ancient term. Old Akkadian
qunnabtu, Neo-
Assyrian and Neo-
Babylonian qunnabu were used to refer to the plant meaning "a way to produce smoke."
[6][7][8]
Description
Cannabis is an
annual,
dioecious,
flowering herb. The
leaves are
palmately compound or digitate, with
serrate leaflets.
[9] The first pair of leaves usually have a single leaflet, the number gradually increasing up to a maximum of about thirteen leaflets per leaf (usually seven or nine), depending on variety and growing conditions. At the top of a flowering plant, this number again diminishes to a single leaflet per leaf. The lower leaf pairs usually occur in an opposite
leaf arrangement and the upper leaf pairs in an alternate arrangement on the main stem of a mature plant.
Cannabis normally has
imperfect flowers, with
staminate "male" and
pistillate "female" flowers occurring on separate plants.
[10] It is not unusual, however, for individual plants to bear both male and female flowers.
[11] Although monoecious plants are often referred to as "hermaphrodites," true hermaphrodites (which are less common) bear staminate and pistillate structures on individual flowers, whereas monoecious plants bear male and female flowers at different locations on the same plant. Male flowers are normally borne on loose
panicles, and female flowers are borne on
racemes.
[12] "At a very early period the Chinese recognized the Cannabis plant as dioecious,"
[13] and the (ca. 3rd century BCE)
Erya dictionary defined
xi 枲 "male cannabis" and
fu 莩 (or
ju 苴) "female cannabis".
[14]

Cannabis is growing like
weeds at the foot of
Dhaulagiri.
All known strains of
Cannabis are
wind-pollinated[15] and produce "
seeds" that are technically
achenes.
[16] Most strains of
Cannabis are
short day plants,
[15] with the possible exception of
C. sativa subsp.
sativa var.
spontanea (=
C. ruderalis), which is commonly described as "auto-flowering" and may be
day-neutral.
Cannabis, like many organisms, is
diploid, having a
chromosome complement of 2n=20, although polyploid individuals have been artificially produced.
[17] The plant is believed to have originated in the mountainous regions northwest of the Himalayas. It is also known as hemp, although this term is often used to refer only to varieties of
Cannabis cultivated for non-drug use.
Cannabis plants produce a group of chemicals called cannabinoids, which produce mental and physical effects when consumed.
Cannabinoids,
terpenoids, and other compounds are secreted by glandular
trichomes that occur most abundantly on the floral
calyxes and
bracts of female plants.
[18] As a drug it usually comes in the form of dried flower buds (
marijuana),
resin (
hashish), or various extracts collectively known as
hashish oil.
[3] In the early 20th century, it became illegal in most of the world to cultivate or possess
Cannabis for sale or personal use.
Taxonomy
Cannabis leaf
The genus
Cannabis was formerly placed in the
Nettle (
Urticaceae) or
Mulberry (
Moraceae) family, but is now considered along with
hops (
Humulus sp.) to belong to the
Hemp family (
Cannabaceae).
[19] Recent
phylogenetic studies based on
cpDNA restriction site analysis and
gene sequencing[
disambiguation needed] strongly suggest that the Cannabaceae arose from within the
Celtidaceae clade, and that the two families should be merged to form a single
monophyletic group.
[20][21]
Various types of
Cannabis have been described, and classified as
species,
subspecies, or
varieties:
[22]
- plants cultivated for fiber and seed production, described as low-intoxicant, non-drug, or fiber types.
- plants cultivated for drug production, described as high-intoxicant or drug types.
- escaped or wild forms of either of the above types.

Leaf of a
Cannabis plant
Cannabis plants produce a unique family of terpeno-phenolic compounds called cannabinoids, which produce the "high" one experiences from smoking marijuana. The two cannabinoids usually produced in greatest abundance are cannabidiol (
CBD) and/or Δ9-tetrahydrocannabinol (
THC), but only THC is psychoactive. Since the early 1970s,
Cannabis plants have been categorized by their chemical
phenotype or "chemotype," based on the overall amount of THC produced, and on the ratio of THC to CBD.
[23] Although overall
cannabinoid production is influenced by environmental factors, the THC/CBD ratio is genetically determined and remains fixed throughout the life of a plant.
[24] Non-drug plants produce relatively low levels of THC and high levels of CBD, while drug plants produce high levels of THC and low levels of CBD. When plants of these two chemotypes cross-pollinate, the plants in the first filial (F1) generation have an intermediate chemotype and produce similar amounts of CBD and THC. Female plants of this chemotype may produce enough THC to be utilized for drug production.
[23][25]

Top of
Cannabis plant in vegetative growth stage
Whether the drug and non-drug, cultivated and wild types of
Cannabis constitute a single, highly variable species, or the genus is polytypic with more than one species, has been a subject of debate for well over two centuries. This is a contentious issue because there is no universally accepted definition of a
species.
[26] One widely applied criterion for species recognition is that species are "groups of actually or potentially interbreeding natural populations which are reproductively isolated from other such groups."
[27] Populations that are physiologically capable of interbreeding, but morphologically or genetically divergent and isolated by geography or ecology, are sometimes considered to be separate species.
[27] Physiological barriers to reproduction are not known to occur within
Cannabis, and plants from widely divergent sources are interfertile.
[17] However, physical barriers to gene exchange (such as the Himalayan mountain range) might have enabled
Cannabis gene pools to diverge before the onset of human intervention, resulting in speciation.
[28] It remains controversial whether sufficient morphological and
genetic divergence occurs within the genus as a result of geographical or ecological isolation to justify recognition of more than one species.
[29][30][31]
Early classifications

Relative size of varieties of
Cannabis
The
Cannabis genus was first
classified using the "modern" system of taxonomic
nomenclature by
Carolus Linnaeus in 1753, who devised the system still in use for the naming of species.
[32] He considered the genus to be monotypic, having just a single species that he named
Cannabis sativa L. (L. stands for Linnaeus, and indicates the authority who first named the species). Linnaeus was familiar with European hemp, which was widely cultivated at the time. In 1785, noted evolutionary biologist
Jean-Baptiste de Lamarck published a description of a second species of
Cannabis, which he named
Cannabis indica Lam.
[33] Lamarck based his description of the newly named species on plant specimens collected in India. He described
C. indica as having poorer fiber quality than
C. sativa, but greater utility as an
inebriant. Additional
Cannabis species were proposed in the 19th century, including strains from China and Vietnam (Indo-China) assigned the names
Cannabis chinensis Delile, and
Cannabis gigantea Delile ex Vilmorin.
[34] However, many taxonomists found these putative species difficult to distinguish. In the early 20th century, the single-species concept was still widely accepted, except in the
Soviet Union where
Cannabis continued to be the subject of active taxonomic study. The name
Cannabis indica was listed in various
Pharmacopoeias, and was widely used to designate
Cannabis suitable for the manufacture of medicinal preparations.
[35]
20th Century
Cannabis ruderalis
In 1924, Russian botanist D.E. Janichevsky concluded that
ruderal Cannabis in central Russia is either a variety of
C. sativa or a separate species, and proposed
C. sativa L. var.
ruderalis Janisch. and
Cannabis ruderalis Janisch. as alternative names.
[22] In 1929, renowned plant explorer
Nikolai Vavilov assigned wild or feral populations of
Cannabis in Afghanistan to
C. indica Lam. var.
kafiristanica Vav., and ruderal populations in Europe to
C. sativa L. var.
spontanea Vav.
[25][34] In 1940, Russian botanists Serebriakova and Sizov proposed a complex classification in which they also recognized
C. sativa and
C. indica as separate species. Within
C. sativa they recognized two subspecies:
C. sativa L. subsp.
culta Serebr. (consisting of cultivated plants), and
C. sativa L. subsp.
spontanea (Vav.) Serebr. (consisting of wild or feral plants). Serebriakova and Sizov split the two
C. sativa subspecies into 13 varieties, including four distinct groups within subspecies
culta. However, they did not divide
C. indica into subspecies or varieties.
[22][36] This excessive splitting of
C. sativa proved too unwieldy, and never gained many adherents.
In the 1970s, the taxonomic classification of
Cannabis took on added significance in North America. Laws prohibiting
Cannabis in the
United States and
Canada specifically named products of
C. sativa as prohibited materials. Enterprising attorneys for the defense in a few drug busts argued that the seized
Cannabis material may not have been
C. sativa, and was therefore not prohibited by law. Attorneys on both sides recruited botanists to provide expert testimony. Among those testifying for the prosecution was Dr. Ernest Small, while
Dr. Richard E. Schultes and others testified for the defense. The botanists engaged in heated debate (outside of court), and both camps impugned the other's integrity.
[29][30] The defense attorneys were not often successful in winning their case, because the intent of the law was clear.
[37]
In 1976, Canadian botanist Ernest Small
[38] and American taxonomist
Arthur Cronquist published a taxonomic revision that recognizes a single species of
Cannabis with two subspecies:
C. sativa L. subsp.
sativa, and
C. sativa L. subsp.
indica (Lam.) Small & Cronq.
[34] The authors hypothesized that the two subspecies diverged primarily as a result of human selection;
C. sativa subsp.
sativa was presumably
selected for traits that enhance fiber or seed production, whereas
C. sativa subsp.
indica was primarily selected for drug production. Within these two subspecies, Small and Cronquist described
C. sativa L. subsp.
sativa var.
spontanea Vav. as a wild or escaped variety of low-intoxicant
Cannabis, and
C. sativa subsp.
indica var.
kafiristanica (Vav.) Small & Cronq. as a wild or escaped variety of the high-intoxicant type. This classification was based on several factors including interfertility, chromosome uniformity, chemotype, and numerical analysis of
phenotypic characters.
[23][34][39]
Professors William Emboden, Loran Anderson, and Harvard botanist
Richard E. Schultes and coworkers also conducted taxonomic studies of
Cannabis in the 1970s, and concluded that stable
morphological differences exist that support recognition of at least three species,
C. sativa,
C. indica, and
C. ruderalis.[40][41][42][43] For Schultes, this was a reversal of his previous interpretation that
Cannabis is monotypic, with only a single species.
[44] According to Schultes' and Anderson's descriptions,
C. sativa is tall and laxly branched with relatively narrow leaflets,
C. indica is shorter, conical in shape, and has relatively wide leaflets, and
C. ruderalis is short, branchless, and grows wild in
central Asia. This taxonomic interpretation was embraced by
Cannabis aficionados who commonly distinguish narrow-leafed "sativa" drug
strains from wide-leafed "indica" drug strains.
[45]
Continuing research
Molecular analytical techniques developed in the late 20th century are being applied to questions of taxonomic classification. This has resulted in many reclassifications based on
evolutionary systematics. Several studies of Random Amplified Polymorphic DNA (
RAPD) and other types of genetic markers have been conducted on drug and fiber strains of
Cannabis, primarily for
plant breeding and forensic purposes.
[46][47][48][49][50] Dutch
Cannabis researcher E.P.M. de Meijer and coworkers described some of their RAPD studies as showing an "extremely high" degree of genetic polymorphism between and within populations, suggesting a high degree of potential variation for selection, even in heavily selected hemp cultivars.
[24] They also commented that these analyses confirm the continuity of the
Cannabis gene pool throughout the studied accessions, and provide further confirmation that the genus comprises a single species, although theirs was not a systematic study
per se.
Karl W. Hillig, a
graduate student in the laboratory of long-time
Cannabis researcher Paul G. Mahlberg
[51] at
Indiana University, conducted a systematic investigation of genetic, morphological, and
chemotaxonomic variation among 157
Cannabis accessions of known geographic origin, including fiber, drug, and feral populations. In 2004, Hillig and Mahlberg published a chemotaxomic analysis of cannabinoid variation in their
Cannabis germplasm collection. They used
gas chromatography to determine cannabinoid content and to infer
allele frequencies of the
gene that controls CBD and THC production within the studied populations, and concluded that the patterns of cannabinoid variation support recognition of
C. sativa and
C. indica as separate species, but not
C. ruderalis.[25] The authors assigned fiber/seed landraces and feral populations from Europe, central Asia, and Asia Minor to
C. sativa. Narrow-leaflet and wide-leaflet drug accessions, southern and eastern Asian hemp accessions, and feral Himalayan populations were assigned to
C. indica. In 2005, Hillig published a
genetic analysis of the same set of accessions (this paper was the first in the series, but was delayed in publication), and proposed a three-species classification, recognizing
C. sativa,
C. indica, and (tentatively)
C. ruderalis.
[28] In his doctoral
dissertation published the same year, Hillig stated that
principal components analysis of
phenotypic (morphological) traits failed to differentiate the putative species, but that
canonical variates analysis resulted in a high degree of discrimination of the putative species and infraspecific taxa.
[52] Another paper in the series on chemotaxonomic variation in the
terpenoid content of the
essential oil of
Cannabis revealed that several wide-leaflet drug strains in the collection had relatively high levels of certain
sesquiterpene alcohols, including guaiol and isomers of eudesmol, that set them apart from the other putative taxa.
[53] Hillig concluded that the patterns of genetic, morphological, and chemotaxonomic variation support recognition of
C. sativa and
C. indica as separate species. He also concluded there is little support to treat
C. ruderalis as a separate species from
C. sativa at this time, but more research on wild and weedy populations is needed because they were underrepresented in their collection.
In September 2005,
New Scientist reported that researchers at the Canberra Institute of Technology had identified a new type of
Cannabis based on analysis of
mitochondrial and
chloroplast DNA.
[54] The New Scientist story, which was picked up by many news agencies and web sites, indicated that the research was to be published in the journal
Forensic Science International.
[55]
Popular usage
The scientific debate regarding taxonomy has had little effect on the terminology in widespread use among cultivators and users of drug-type
Cannabis.
Cannabis aficionados recognize three distinct types based on such factors as morphology,
native range, aroma, and subjective psychoactive characteristics. "Sativa" is the term used to describe the most widespread variety, which is usually tall, laxly branched, and found in warm lowland regions. "Indica" is used to designate shorter, bushier plants adapted to cooler climates and highland environments. "Ruderalis" is the term used to describe the short plants that grow wild in Europe and central Asia.
Breeders, seed companies, and cultivators of drug type
Cannabis often describe the ancestry or gross
phenotypic characteristics of
cultivars by categorizing them as "pure indica," "mostly indica," "indica/sativa," "mostly sativa", or "pure sativa."
On of the most popular and potent sativas in Africa is
Malawi Gold, locally known as
chamba. It is internationally renowed for its potency and its flavor.
Reproduction
Breeding systems
Cannabis sativa seeds.
Cannabis is predominantly
dioecious,
[15][56] although many monoecious varieties have been described.
[57] Subdioecy (the occurrence of monoecious individuals and dioecious individuals within the same population) is widespread.
[58][59][60] Many populations have been described as sexually labile.
[48][61][62]
Cannabis flower with visible
trichomes.

Male
Cannabis pollen sacs.
As a result of intensive selection in cultivation,
Cannabis exhibits many sexual phenotypes that can be described in terms of the ratio of female to male flowers occurring in the individual, or typical in the cultivar.
[63] Dioecious varieties are preferred for drug production, where typically the female flowers are used. Dioecious varieties are also preferred for textile fiber production, whereas monoecious varieties are preferred for pulp and paper production. It has been suggested that the presence of monoecy can be used to differentiate licit crops of monoecious hemp from illicit drug crops.
[58] However, the so-called "sativa" drug strains often produce monoecious individuals, probably as a result of inbreeding.
Mechanisms of sex determination
Cannabis has been described as having one of the most complicated mechanisms of
sex determination among the dioecious plants.
[63] Many models have been proposed to explain sex determination in
Cannabis.
Based on studies of sex reversal in
hemp, it was first reported by K. Hirata in 1924 that an
XY sex-determination system is present.
[61] At the time, the XY system was the only known system of sex determination. The
X:A system was first described in Drosophila spp in 1925.
[64] Soon thereafter, Schaffner disputed Hirata's interpretation,
[65] and published results from his own studies of sex reversal in hemp, concluding that an X:A system was in use and that furthermore sex was strongly influenced by environmental conditions.
[62]
Since then, many different types of sex determination systems have been discovered, particularly in plants.
[56] Dioecy is relatively uncommon in the plant kingdom, and a very low percentage of dioecious plant species have been determined to use the XY system. In most cases where the XY system is found it is believed to have evolved recently and independently.
[66]
Since the 1920s, a number of sex determination models have been proposed for
Cannabis. Ainsworth describes sex determination in the genus as using "an X/autosome dosage type".
[56]

A male hemp plant.

Dense raceme of carpellate flowers typical of drug-type varieties of
Cannabis.
The question of whether heteromorphic sex chromosomes are indeed present is most conveniently answered if such chromosomes were clearly visible in a
karyotype.
Cannabis was one of the first plant species to be karyotyped; however, this was in a period when karyotype preparation was primitive by modern standards (see
History of Cytogenetics). Heteromorphic sex chromosomes were reported to occur in staminate individuals of dioecious "Kentucky" hemp, but were not found in pistillate individuals of the same variety. Dioecious "Kentucky" hemp was assumed to use an XY mechanism. Heterosomes were not observed in analyzed individuals of monoecious "Kentucky" hemp, nor in an unidentified German cultivar. These varieties were assumed to have sex chromosome composition XX.
[67] According to other researchers, no modern karyotype of
Cannabis had been published as of 1996.
[68] Proponents of the XY system state that
Y chromosome is slightly larger than the X, but difficult to differentiate cytologically.
[69]
More recently, Sakamoto and various co-authors
[70][71] have used
RAPD to isolate several
genetic marker sequences that they name Male-Associated DNA in
Cannabis (MADC), and which they interpret as indirect evidence of a male chromosome. Several other research groups have reported identification of male-associated markers using RAPD and
AFLP.
[24][48][72] Ainsworth commented on these findings, stating,
"It is not surprising that male-associated markers are relatively abundant. In dioecious plants where sex chromosomes have not been identified, markers for maleness indicate either the presence of sex chromosomes which have not been distinguished by cytological methods or that the marker is tightly linked to a gene involved in sex determination.
[56] "
Environmental sex determination is known to occur in a variety of species.
[73] Many researchers have suggested that sex in
Cannabis is determined or strongly influenced by environmental factors.
[62] Ainsworth reviews that treatment with
auxin and
ethylene have feminizing effects, and that treatment with
cytokinins and
gibberellins have masculinizing effects.
[56] It has been reported that sex can be reversed in
Cannabis using chemical treatment.
[74] A
PCR-based method for the detection of female-associated
DNA polymorphisms by
genotyping has been developed.
[75]
Industrial and personal uses
Cannabis is used for a wide variety of purposes.
Hemp
Main article:
Hemp
Hemp is the natural, durable soft fiber from the
stalk of
Cannabis sativa plants that grow upwards of 20 feet tall. Cannabis plants used for hemp production are not valued for recreational uses as the plants that are cultivated for hemp produce minimal levels of
THC, analogous to attempting to get
drunk from
low-alcohol beer.
Cannabis plants intended for any drug cultivation is not so easy to hide in a hemp field either, as the size and height of each are significantly different.
[76]
Hemp producers sell hemp seeds as a health food, as they are rich in heart-healthy,
essential fatty acids,
amino acids (both essential and nonessential),
vitamins and
minerals. Hemp "milk" is a milk substitute also made from hemp seeds that is both dairy and gluten-free.
[77]
Hemp is fairly easy to grow and matures very fast compared to many crops; the growth is however in no way exceptional.
[78] Compared to
cotton for clothing, hemp cloth is known to be of superior strength and longer-lasting. The fibers may also be used to form
cordage for industrial-strength ropes. Hemp plants also require little pesticides and herbicides because of their height, density and foliage. This also makes the hemp plant environmentally very friendly (with the exception of the chemical fertilizers used in industrial agriculture). The world leading producer of hemp is
China.
[79]
Hemp can be utilized for 25,000 very durable textile products,
[76] ranging from
paper and
clothing to
biofuels (from the oils found in the seeds),
medicines and
construction material. Hemp has been used by many civilizations, from
China to
Europe (and later
North America) for the last 12,000 years of history.
[76][80]
Recreational use
Main article:
Cannabis (drug)
See also:
Tetrahydrocannabinol,
Cannabidiol, and
Effects of cannabis
Cannabis Museum in
Amsterdam.

Comparison of physical harm and dependence regarding various drugs.
[81]
Cannabis is a popular recreational drug around the world, only behind
alcohol,
caffeine and
tobacco. In the United States alone, it is believed that over 100 million Americans have tried Cannabis, with 25 million Americans having used it within the past year.
[82]
The psychoactive effects of Cannabis are known to have a biphasic nature. Primary psychoactive effects include a state of relaxation, and to a lesser degree, euphoria from its main psychoactive compound,
tetrahydrocannabinol. Secondary psychoactive effects, such as a facility for philosophical thinking;
introspection and
metacognition have been reported, amongst cases of
anxiety and
paranoia.
[83] Finally, the tertiary psychoactive effects of the drug cannabis, can include an increase in heart rate and hunger, believed to be caused by
11-Hydroxy-THC, a psychoactive metabolite of
THC produced in the
liver.
Normal cognition is restored after approximately three hours for larger doses via a
smoking pipe,
bong or
vaporizer.
[83] However, if a large amount is taken orally the effects may last much longer. After 24 hours to a few days, minuscule psychoactive effects may be felt, depending on dosage, frequency and tolerance to the drug.
Various
forms of the drug cannabis exist, including extracts such as hashish and hash oil
[3] which, because of appearance, are more susceptible to
adulterants when left unregulated.
The plant
Cannabis sativa is known to cause more of a "high" by stimulating hunger and by producing a rather more comedic, or energetic feeling. Conversely, the
Cannabis indica plant is known to cause more of a "stoned" or meditative feeling, possibly because of a higher CBD to THC ratio.
[84]
Cannabidiol (CBD), which has no psychotropic effects by itself
[85] (although sometimes showing a small stimulant effect, similar to
caffeine),[
citation needed] attenuates, or reduces
[86] the higher anxiety levels caused by
THC alone.
[87]
According to the UK medical journal
The Lancet, Cannabis has a lower rate of
dependence compared to both nicotine and alcohol.
[88] However, everyday use of Cannabis can in some cases, be correlated with some psychological
withdrawal symptoms such as irritability, and insomnia
[83] and evidence could suggest that if a user experiences stress, the likeliness of getting a
panic attack increases because of an increase of THC metabolites.
[89][90] However, any Cannabis withdrawal symptoms are typically mild and are never life-threatening.
[88]
Medical use
Main article:
Medical cannabis
A synthetic form of the main psychoactive cannabinoid in
Cannabis, Δ9-tetrahydrocannabinol (THC), is used as a treatment for a wide range of medical conditions.
[91]
In the United States, although the
Food and Drug Administration (FDA) does acknowledge that "there has been considerable interest in its use for the treatment of a number of conditions, including glaucoma, AIDS wasting, neuropathic pain, treatment of spasticity associated with multiple sclerosis, and chemotherapy-induced nausea," the agency has not approved "medical marijuana". There are currently 2 oral forms of cannabis (cannabinoids) available by prescription in the United States for nausea and vomiting associated with cancer chemotherapy: dronabinol (Marinol) and nabilone (Cesamet). Dronabinol is also approved for the treatment of anorexia associated with AIDS.
[92] The FDA does facilitate scientific investigations into the medical uses of
cannabinoids.
[93]
In a collection of writings on medical marijuana by 45 researchers, a literature review on the medicinal uses of
Cannabis and cannabinoids concluded that established uses include easing of nausea and vomiting, anorexia, and weight loss; "well-confirmed effect" was found in the treatment of spasticity, painful conditions (i.e. neurogenic pain), movement disorders, asthma, and glaucoma. Reported but "less-confirmed" effects included treatment of allergies, inflammation, infection, epilepsy, depression,
bipolar disorders,
anxiety disorder, dependency and withdrawal. Basic level research was being carried out at the time on
autoimmune disease, cancer, neuroprotection, fever, disorders of blood pressure.
[94]
Clinical trials conducted by the American
Marijuana Policy Project, have shown the efficacy of cannabis as a treatment for cancer and
AIDS patients, who often suffer from clinical depression, and from nausea and resulting weight loss due to
chemotherapy and other aggressive treatments.
[95] A synthetic version of the cannabinoid THC named
dronabinol has been shown to relieve symptoms of anorexia and reduce agitation in elderly Alzheimer's patients.
[96] Dronabinol has been approved for use with anorexia in patients with HIV/
AIDS and chemotherapy-related nausea. This drug, while demonstrating the effectiveness of
Cannabis at combating several disorders, is more expensive and less available than whole cannabis and has not been shown to be effective or safe.
[97]
Glaucoma, a condition of increased pressure within the eyeball causing gradual loss of sight, can be treated with medical marijuana to decrease this
intraocular pressure. There has been debate for 25 years on the subject. Some studies have shown a reduction of IOP in glaucoma patients who smoke cannabis,
[98] but the effects are generally short-lived. There exists some concern over its use since it can also decrease blood flow to the optic nerve. Marijuana lowers IOP by acting on a
cannabinoid receptor on the
ciliary body called the CB receptor.
[99] Although
Cannabis may not be the best therapeutic choice for glaucoma patients, it may lead researchers to more effective treatments. A promising study shows that agents targeted to ocular CB receptors can reduce IOP in glaucoma patients who have failed other therapies.
[100]
Medical cannabis is also used for
analgesia, or pain relief. It is also reported to be beneficial for treating certain neurological illnesses such as epilepsy, and bipolar disorder.
[101] Case reports have found that
Cannabis can relieve
tics in people with
obsessive compulsive disorder and
Tourette syndrome. Patients treated with
tetrahydrocannabinol, the main psychoactive chemical found in
Cannabis, reported a significant decrease in both motor and vocal tics, some of 50% or more.
[102][103][104] Some decrease in obsessive-compulsive behavior was also found.
[102] A recent study has also concluded that cannabinoids found in
Cannabis might have the ability to prevent Alzheimer's disease.
[105] THC has been shown to reduce arterial blockages.
[106]
Another potential use for medical cannabis is movement disorders.
Cannabis is frequently reported to reduce the muscle spasms associated with
multiple sclerosis; this has been acknowledged by the
Institute of Medicine, but it noted that these abundant anecdotal reports are not well-supported by clinical data. Evidence from animal studies suggests that there is a possible role for cannabinoids in the treatment of certain types of epileptic seizures.
[107] A synthetic version of the major active compound in
Cannabis, THC, is available in capsule form as the prescription drug
dronabinol (Marinol) in many countries. The prescription drug
Sativex, an extract of cannabis administered as a
sublingual spray, has been approved in Canada for the treatment of multiple sclerosis.
[108]
Cannabis was manufactured and sold by U.S. pharmaceutical companies from the 1880s through the 1930s, but the lack of documented information on the frequency and effectiveness of its use makes it difficult to evaluate its medicinal value in these forms. Cannabis was listed in the
1929–1930 Physicians' Catalog of the Pharmaceutical and Biological Products of Parke, Davis & Company as an active ingredient in ten products for cough, colic, neuralgia, cholera mordus and other medical conditions, as well as a "narcotic, analgesic, and sedative."
[109] The
1929–1930 Physicians' Catalog also lists compound medications containing cannabis that in some cases were apparently formulated by medical doctors, in its "Pills and Tablets" section
[110]
As cannabis is further legalized for medicinal use, it is possible that some of the foregoing compound medicines, whose formulas have been copied exactly as published, may be scientifically tested to determine whether they are effective medications. Writing in the
Canadian Medical Association Journal, smoking cannabis from a pipe may significantly relieve chronic pain in patients with damaged nerves.
[111]
Ancient and religious uses
Main article:
Religious and spiritual use of cannabis
The Yanghai Tombs, a vast ancient cemetery (54 000 m2) situated in the
Turfan district of the
Xinjiang Uyghur Autonomous Region of the
People's Republic of China, have revealed the 2700-year-old grave of a
shaman. He is thought to have belonged to the
Jushi culture recorded in the area centuries later in the
Hanshu, Chap 96B.
[112] Near the head and foot of the shaman was a large leather basket and wooden bowl filled with 789g of cannabis, superbly preserved by climatic and burial conditions. An international team demonstrated that this material contained
tetrahydrocannabinol, the psychoactive component of cannabis. The cannabis was presumably employed by this culture as a medicinal or psychoactive agent, or an aid to divination. This is the oldest documentation of cannabis as a pharmacologically active agent.
[113]
Settlements which date from
c. 2200-1700 BCE in the
Bactria and
Margiana contained elaborate ritual structures with rooms containing everything needed for making drinks containing extracts from poppy (opium), hemp (cannabis), and
ephedra (which contains
ephedrine).
[114]
"While we have no evidence of the use of ephedra among the steppe tribes, we have already seen that they did share in the cultic use of hemp, a practice that ranged from
Romania east to the
Yenisei River from at least the 3rd millenium BC onwards where its use was later encountered in the apparatus for smoking hemp found at
Pazyryk."
[115]
Cannabis is first referred to in
Hindu Vedas between 2000 and 1400 BCE, in the
Atharvaveda. By the 10th century CE, it has been suggested that it was referred to by some in India as "food of the gods".
[116] Cannabis use eventually became a ritual part of the Hindu festival of
Holi.
In
Buddhism, cannabis is generally regarded as an intoxicant and therefore a hindrance to development of meditation and clear awareness. In ancient
Germanic culture,
Cannabis was associated with the
Norse love goddess,
Freya.
[117][118] An anointing oil mentioned in Exodus is, by some translators, said to contain
Cannabis.
[119] Sufis have used
Cannabis in a spiritual context since the 13th century CE.
[120]
In India today,
ganja is offered to the god
Shiva, as well as consumed by
Shaivite yogis and devotees. Charas is smoked by some Shaivite devotees and cannabis itself is seen as a ("prasad", or offering) to Shiva to aid in
sadhana.
In modern times the
Rastafari movement has embraced
Cannabis as a sacrament.
[121] Elders of the modern
religious movement known as the
Ethiopian Zion Coptic Church consider
Cannabis to be the
Eucharist, claiming it as an oral tradition from
Ethiopia dating back to the time of
Christ, even though the movement was founded in the
United States in 1975 and has no ties to either Ethiopia or the Coptic Church.
[122] Like the Rastafari, some modern
Gnostic Christian sects have asserted that
Cannabis is the
Tree of Life.
[123][124] Other organized
religions founded in the 20th century that treat
Cannabis as a
sacrament are the
THC Ministry,
[125] the
Way of Infinite Harmony,
Cantheism,
[126] the
Cannabis Assembly[127] and the
Church of Cognizance.
Aspects of Cannabis production and use
Cannabis field seized by authorities.