What is your ph, watering schedule, growing medium, canopy temperature, and nute brand? Also, where did this leaf come from... the top, bottom, or middle of the plant and then from the light-source side, etc.? Do all other leaves share this, or is it localized to the top few, etc.?
first class heat stress, guess you bit close to your lights or grow in a way to hot placeYeah here is a shot