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Chemistry and Biological Activity of Tetrahydrocannabinol and its Derivatives
Book SeriesTopics in Heterocyclic ChemistryPublisherSpringer Berlin / HeidelbergISSN1861-9282 (Print) 1861-9290 (Online)VolumeVolume 10/2007BookBioactive Heterocycles IVDOI10.1007/978-3-540-73404-8Copyright2007ISBN978-3-540-73403-1DOI10.1007/7081_2007_084Pages1-42Subject CollectionChemistry and Materials ScienceSpringerLink DateTuesday, August 14, 2007
T. Flemming1, 2, R. Muntendam2, C. Steup1 and Oliver Kayser3
(1) THC-Pharm Ltd., Offenbacher Landstrasse 368A, 60599 Frankfurt, Germany(2) Department of Pharmaceutical Biology, GUIDE, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands(3) Department of Pharmaceutical Biology, Groningen Research Institute for Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
Abstract
Cannabinoids and in particular the main psychoactive Δ9-THC are promising substances for the development of new drugs and are of high importance in biomedicine and pharmacy. This review gives an overview of the chemical properties of Δ9-THC, its synthesis on industrial scale, and the synthesis of important metabolites. The biosynthesis of cannabinoids in Cannabis sativa is extensively described in addition to strategies for optimization of this plant for cannabinoid employment in medicine. The metabolism of Δ9-THC in humans is shown and, based on this, analytical procedures for cannabinoids and their metabolites in human forensic samples as well as in C. sativa will be discussed. Furthermore, some aspects of medicinal indications for Δ9-THC and its ways of administration are described. Finally, some synthetic cannabinoids and their importance in research and medicine are delineated.
Book SeriesTopics in Heterocyclic ChemistryPublisherSpringer Berlin / HeidelbergISSN1861-9282 (Print) 1861-9290 (Online)VolumeVolume 10/2007BookBioactive Heterocycles IVDOI10.1007/978-3-540-73404-8Copyright2007ISBN978-3-540-73403-1DOI10.1007/7081_2007_084Pages1-42Subject CollectionChemistry and Materials ScienceSpringerLink DateTuesday, August 14, 2007
T. Flemming1, 2, R. Muntendam2, C. Steup1 and Oliver Kayser3

(1) THC-Pharm Ltd., Offenbacher Landstrasse 368A, 60599 Frankfurt, Germany(2) Department of Pharmaceutical Biology, GUIDE, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands(3) Department of Pharmaceutical Biology, Groningen Research Institute for Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
Abstract
Cannabinoids and in particular the main psychoactive Δ9-THC are promising substances for the development of new drugs and are of high importance in biomedicine and pharmacy. This review gives an overview of the chemical properties of Δ9-THC, its synthesis on industrial scale, and the synthesis of important metabolites. The biosynthesis of cannabinoids in Cannabis sativa is extensively described in addition to strategies for optimization of this plant for cannabinoid employment in medicine. The metabolism of Δ9-THC in humans is shown and, based on this, analytical procedures for cannabinoids and their metabolites in human forensic samples as well as in C. sativa will be discussed. Furthermore, some aspects of medicinal indications for Δ9-THC and its ways of administration are described. Finally, some synthetic cannabinoids and their importance in research and medicine are delineated.