No it shouldn't. At that stage it is more likely that the plants are experiencing senescence, end of life. Yellowing fan leaves is natural at that point. However, you should still have green on the leaves until the end of cycle. If the yellowing is happening very quickly, it could be possible the plant is underfed or has pH imbalance in the root zone. Pictures and more info about feeding/medium/pH would help. But no, 50-65% humidity is ideal (depending on temperature) and should not cause any problems.