I'd set it up to where you're whole system is the right size so that doesn't need to happen. Using 5 gal bucket sites and an 8-15gal res, buckets hold 3.5-4 gals FULL and res 6-12. When they're at that stage in flower, they should be straight GULPING that solution down. It gets to the point where the system FULL totals 34-44gallons and within a matter of 4-6 days, it's nearly empty. Res changes aren't even needed because there ain't nothing left to change!
As for your question on flushing, you'll get varying opinions, but I see no harm in using JUST RO water around when you think they've got about 10-14 days left on them, to refill your system to mix with the remainder. Usually, yellowing/fading top fan leaves are a good indicator it's at about that point. That way your PPMs are dropped significantly over time. Bdy the last day, it's less than 100 where it started at 450-600.