You are asking for advice without giving enough info.
You've mentioned "mild powders" but I have no idea what that means.
Sure, the default would be go eat some LSD or shrooms, I mean, look at what board you are posting to.
But:
#1 - What is your set and setting?
If this question does not mean anything, go research it. It is the most important question to ask before doing ANY psychedelics.
After you come back and say: Great, kick ass, wonderful, pretty good, um, got troubles, uhoh, living in shithole and am depressed. (choose one), you can then answer yourself which (if any) of the brain candy to try.
I've got 30 years experience, and I KNEW NOT to do ANYTHING for the last 6 months while my life is in a state of transition. Just moved into a new house, everything is f'ing great, so NOW I can play.
If your life is generally good any you are looking for an adventure, with energy and 6-10 hour trip time, I'd say go for the LSD.
If you prefer a more relaxed time, and can handle a bit of body load (really, depends on you and the shrooms and the method of ingestion), and you are looking for deep introspection, and you want a 3-6 hours trip, go for some shrooms.
Note: You will probably be altered for about 6 months after the shrooms. In most cases you'll be a much nicer more open person. It may last longer, but a maintenance dose might be helpful at that point if you want to be sure. On the other hand, if you don't want to be that person, don't do the shrooms. I can't be sure any of the others won't affect you that way, but it has been proven in shroom studies (mayo clinic maybe, ahh, gotta google but no time now)
If you are looking for 15 minutes of interaction with the god(s) of your choice, go do some DMT.
All depend on set and setting being right to have a good (actually no guarantee of good, but always worthwhile) time. All can FUCK YOU UP BAD (some short term, some long, really impossible to measure) if you are not ready for them.
Have fun, be careful.