Chemistry Discussion Thread

[VLRD.Kush]

I did do the test a few weeks ago, and it does make the glucose level go up. I was just curious as of why, and it seems there isn't a for sure answer.

 

[cannabineer]

We don't need to do a test, stims cause it that's quite clear. A study into the mechanism would be awesome though.

Found this. cn

Sympathomimetics may increase blood sugar via stimulation of beta2-receptors which leads to increased glycogenolysis.

 

[cannabineer]

A little humor for the thread. cn

 

[morfin56]

Haha I like that picture.

 

[MrEDuck]

That's one of my wife's favorite jokes.

 

[morfin56]

Mr.E.
Would safrole to MDP2P to MDMA yield higher then safrole to MDA to MDMA?

 

[MrEDuck]

I've never synthed MDMA from MDA so I can't say for certain but as a general rule less reactions make for a better overall yield. Also the yields from reductive ammination are pretty close for methylamine and ammonia so unless you can N methylate MDA with really high yield the direct synth is better.

 

[cannabineer]

The N-methylation is near quant. if you make the trifluoroacetamide of MDA, methylate that with methyl iodide, then alkalize away the trifluoroacetyl. Like buddah. But without a fume hood, no. cn

 

[morfin56]

Thanks.
After looking at the NASA MDA synth and their yield I thought maybe it would be a better route.

Have you tried a MDP2P synth from piperonal?
Or is safrole still preferred?

I might have to take a trip out to somewhere, where sassafras grows if I can't find a viable alternative.

My understanding is it will be a bitch to get enough piperonal.
Any suggestions?

 

[MrEDuck]

The allyl ether of catechol will isomerize to 4-allylcatechol when heated. There's a paper in Rhodium's archive. You bridge it by reacting it with diiodomethane or dibromomethane (DCM can work but the rxn is slow and the yield is shit) with a strong base and a phase transfer catalyst.

 

[VLRD.Kush]

one more thing...


It would probably be better to check glucose, then consume, check glucose again, then proceed with my evening? Correct?

 

[MrEDuck]

That's how I would do it.

 

[MrEDuck]

Good luck getting gammabutyrolactone in the US. If you manage to get it you mix it with a strong base (lye or KOH works best) in equimolar quantities. I hardly consider it synthesis. Becareful because bases burn horribly, you don't want GBL in your eyes, make sure to dilute the GBL and base with water first.
If you find it be warned that it is extremely addictive and possibly the worst kick known to man.

The Colorado River Toad does not produce DMT, but rather 5-MeO-DMT. Do some research about it. I have no idea how one gets it out as I refuse to harm a living thing in the name of getting high.

 

[canndo]

Good luck getting gammabutyrolactone in the US. If you manage to get it you mix it with a strong base (lye or KOH works best) in equimolar quantities. I hardly consider it synthesis. Becareful because bases burn horribly, you don't want GBL in your eyes, make sure to dilute the GBL and base with water first.
If you find it be warned that it is extremely addictive and possibly the worst kick known to man.

The Colorado River Toad does not produce DMT, but rather 5-MeO-DMT. Do some research about it. I have no idea how one gets it out as I refuse to harm a living thing in the name of getting high.

I am not a big believer in Karma but..... I can't imagine having a pleasant trip knowing that you killed something with awareness in order to have it. I have friends who have gotten this "toad sap" (I believe it was harvested without killing the creature) and none of them reported having a nice time under its influence.

 

[MrEDuck]

I've never wanted to try 5-MeO-DMT based on the experience reports I've read.

 

[ODanksta]

Sorry something happen to my account.. But you don't kill the toad.. It just sprays it out, it takes two weeks for the toad to replace the DMT.. You extract it by rubbing the bottom of the frogs chin.. And you made a comment that you refuse to harm a living thing.. But pot is a living thing and we chop, prune, grind and light her on fire.. Thanks anyways..

 

[MrEDuck]

It's 5-MeO-DMT not DMT. Big difference.

 

[VLRD.Kush]

It's a defense mechanism, so you're stressing the frog until it produces it's "venom", which is hurting it. Regardless, I've heard the amount that they produce per release is so small and it takes forever to build up enough useable product.

Also, comparing a living animal to a living plant is like apples to oranges man. Yeah their both alive, but lets be real here...

 

[keepitcoastal]

process for turning crack into coke... lets just say i wanna know for shits n giggles

or you could do me one better and also say how to turn dried coca leafs into crack too

 

[cannabineer]

It's 5-MeO-DMT not DMT. Big difference.

A fellow I once knew, quite the indole chemist, claimed that the 5-substituteds were the Dark Side. He way waay preferred the 4-substituteds, with an especial fond spot for 4-hydroxy-Mipt. cn