I've got a setup in my basement, and the room actually is "outside" the footprint of the house. It's a hidden room built for cold storage of vegetables. I can keep very good control of it with a dehumidifier and an AC infinity fan and controller. Fan vents into a carbon filter in the laundry room, intake air comes from the same thru a "mushroom" filter. Haven't had any mold or mildew issues at all, and with the controller, fan keeps the room right where I want it. Don't have any smell at all outside the room, I could vent out an old extra chimney stack I've got from an old coal burner, but wife had a fit about the ducting because it's about 12ft away.
All in all, it's the ideal setup for me, hidden from sight, no tent to deal with, no smell, and can control the environment fairly well.