Noopept

Doesn't seem to be a thread on this one. I did a good amount of reading and decided to try out noopept instead of the other nootropics because of references, cost, research and a free sample that I liked of ~30mg.

If you don't know about noopept, just wiki it and read online because I can't say that I know the exact mechanisms of it. But I did read that it is a peptide consisting of only two amino acids, which makes it able to be administered orally. It is part of the racetam family, being 1000x more potent than piracetam(another, well known nootropic).

Anyways, this stuff is great! Nothing but good things to say. I ordered 5g and have been taking 10mg, 2-3 times daily for 4 days now. The full effects supposedly take two weeks. However, there is a noticeable difference to me even after my first dose, but is more present today.
I stayed home two nights ago(day two) and played guitar. To death. I don't understand that impulsion, I've played for years and never really expanded like I did that day. I learned how to play in key signatures which is something I've been neglecting for years. This could have been placebo but I don't think so. I normally have a pretty good grasp on the sensitive differences in my body throughout the day.
I did some experimenting with other drugs in combination:

Last night I ate some mushrooms to see how it was affected and it was slightly.. Affected. My visuals were more 'there', and they stayed pretty full for a good 5 hours, could've been the strain. They were some damn good mushrooms.
Funny thing, usually mushrooms tend to freak me out a bit. I was hearing these 'angelic' noises like I do when I eat too much and I also was having streaks of hair, length and width, flush throughout my body. This is common for me at higher dosages. Starts with me thinking there is hair in my mouth and ends with the sensation flourishing through a lot of my nerves I guess. This all normally frightens me, it's hysteric, but I have dealt with it so many times.. Every time it still manages to scare me though. I 'forget' what it is, similar to how I personally forget the time dialation properties of ketamine until it is experienced. Or any other drug induced sensation that is not in 'normal' reality.
I only ate an eighth, but that's usually enough to make me terrified. I love it though afterwards. Makes for a more interesting experience.
I seemed to ignore these things this time though and just think endlessly.
It was different, I'm having trouble explaining it. They were noticeably more potent(like I said before could be the strain, they were of the higher quality than I see around), and they frightened me less than usual. I seemed to cherish the side effects rather than trying to ignore them.
That's drugs though so who knows.

Today I wanted to experiment with amphetamines and noopept so I took a 20mg IR around 9 this morning along with ~10mg noopept and later on at noon took a 40mg vyvanse. Followed by a dose a couple hours ago of another ~10mg noopept.
Great effects. My mouth doesn't seem to be as dry, the great effects are probably because I'm speeding. Normally I don't like speeding too much but it seems the negative side effects are not as pronounced as when I am not taking noopept.
I've had my speed series', but most times I stopped relatively quickly due to the negative side effects. I'm not gonna do a binder, just wanted to see how they mixed to relate it to how it altered mushrooms. It seems to be different. But I do feel that it's too early for me to make any accurate conclusion to combinations because even though I do know the effect IS present, I can't quite put a finger on what exactly it is doing. I can say that I have nothing bad to say though.

Pros: increased focus, vivid dreams, seems to have a kick when combined but not sure, way less anxiety(which I think may be linked to my altered mushroom and amphetamine experiences as they flare my anxiety), but I like playing around with it. It also in turn helps me communicate better, I remember more of what I read(which I've read contradictions to this in some people, but I generally just remember everything a lot better and have a sort of 'bigger picture' or map in my brain of anything I do from finding my way around town, to reading, writing, communicating.. )
Cons: none yet

Can anyone dumb down how this works in the body? How exactly a peptide works, how a series of amino acids can have this effect? There is so much vocabulary that goes right by.
Experiences? I know someone around here uses noopept.

Interesting stuff man. I've never heard of it. I'll have to read more..... be careful if there's "nothing but good things to say". That might be a bad thing . But I can't talk, because I have no idea what this is.

I'm familiar with pricetam etc.... just not this.

I've never felt a strong desire to try nootropics but they really interest me.
There's plenty of proteins that get used to signal things in the body. Some more specific questions would be nice because a broad answer would be a lengthy post.

• Interesting stuff man. I've never heard of it. I'll have to read more..... be careful if there's "nothing but good things to say". That might be a bad thing

  

  . But I can't talk, because I have no idea what this is.
  
  I'm familiar with pricetam etc.... just not this.​
  
  
  
  

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It could be, you never know I guess, but it seems pretty harmless
My buddy take piracetam and noopept, piracetam at night. I forget what his reasoning was haha, sure it had something to do with dreams.

• I've never felt a strong desire to try nootropics but they really interest me.
  There's plenty of proteins that get used to signal things in the body. Some more specific questions would be nice because a broad answer would be a lengthy post.​
  
  
  
  

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Haha a lengthy post was what I was looking for really, but don't type it out. Starting tomorrow I'm going to start using Khan Academy, and start on biology so that I know how it all works. I feel like I would knew more about this when I was in high school..
It's weird, I'm noticing that I get very bored very quickly if I'm not doing something that is a learning experience.

I'll try to work on the lengthy post for you but I'm easily distracted. Awesome you're going to work on learnign more about this stuff.

Well if you feel up to it, I won't stop you! But it's okay if you don't, don't feel obligated.
It'll be fun it's cool, I finally feel lack of lethargy

Funny, there is a thread about this. I'm currently experimenting with Piracetam.
It's only been a few days, but I noticed similar effects as the OP in regards to "playing guitar" while under its effect.
It does seem to make otherwise tedious, yet demanding, mental tasks more trivial, as well (in my case processing & analyzing experimental data and performing bizarre math).

I am also noticing something 'missing' from the THC high. That lethargy one gets from smoking too much; I don't feel it. I get all of the psychoactive effects but the physical effects seem to be tapered, if not absent.

To be honest, I didn't expect any response (presumed it was a placebo) but there are definite physiological effects. Having Raynaud's Syndrome (mostly during winter) I was surprised to see my fingers looking more flushed. It turns out this is a side effect of Piracetam for which it is prescribed. BONUS!

I'm looking forward to testing it as a study aid over the next week since that is the ultimate test of whether or not nootropics do what they are supposed to.

The guitar thing is weird, I have been playing it a lot more. I can't say that this is a superhuman thing(unless you played day in and day out) but I can say definitely that I have learned a lot more about the guitar than I have before in this interval of time.
Math seems to be way easier than before still. I feel a little more on top of things on a regular basis, started reading a lot more, started using Khan Academy.. Still haven't noticed any negative effects.. No zombie behavior, mood swings.. Nothing.
I just feel that it gives me more of an edge. With a bunch of things, the order that I'm going to efficiently get things done with work, more grace with word flow, it's easier to observe my speech patterns which is good for me because normally I only notice things that I say more often that usual, sometimes. And when I do I just feel like I'm some kind of robot and it makes me anxious. Now I have been having a second thought process of what else to say, like I have more variety. That whole thing relieves anxiety for me.

It is nice to take, but it's not necessary and it's not any sort of instant gratification. I do notice that the way I was doing things before and now are different. I'm probably about 20-30% more productive, and this memory enhancement helps it along the way. That is a big difference over time. I still am a couch potato a lot of the time. But not near as much.
I don't know if a lot of this has to do with recent rough times that I went through about right when I started taking it or if it's the nootropics, venturing to say it's a mixture of both. But I am absolutely sure that it has very noticeable side effects and hasn't caused me any problems.

Well, I have found Piracetam to be more efficacious after 3 weeks. Noopept (~10 days) seems to have some synergistic effect, but it does not work in the same manner. I notice that difference especially when taken alone. It seems to operate in the background more (i.e. memory effects). That's why I question its "1000x stronger than Piracetam" claim. Sure, perhaps on dosage, but not in results.

However, I am doing ~20mgs 2-3x daily.
I recall seeing some evidence amongst the studies showing paradoxical dosage effects (i.e. bimodal distribution between high and low doses). So it is possible I haven't found that sweet spot where the ED50 is. According to Cambridge Memory tests, I seem to be gaining memory, but they are geared more toward short-term testing (I try to do them while ). My working hypothesis is noopept affects long-term encoding/retrieval, while piracetam mainly works in the present--it keeps the wheels greased, I think, would be an appropriate analogy.

One thing I notice for sure is the effect noopept has on removing brain-fog after an evening of exceptional THC plasma levels. So I do know it is doing something in the short-term. And that's one of the funny things about nootropics; healthy people may not notice great benefits (especially younger ones), but stoners and drunks should...dramatically.

I'll be trying the other -racetams soon (Oxi-,Ani-,and Prami-)

Are you still taking 10mgs 2x a day, high|hgih ? Do you still notice direct effects, or is it more subtle for you now?
I wonder how sustainable the effects are. I thought there would be some tolerance buildup to the piracetam, but I haven't noticed any diminishing returns, yet.

New experiment to test for synergy:
800mg Piracetam (1/2 dose)
250mg Oxiracetam (1/3 dose)
75mg Pramiracetam (3/10 dose)
250mg Aniracetam (1/3 dose)
250mg Choline Bitartrate (1/3 daily dose)
1 fried egg (~225mg choline)
2 pieces of buttered toast

I figure I'll add 10mg Noopept in a bit, if I feel it operating. 5 minutes in, and I feel my head starting to glow, as the water-soluble -racteams go to work.
But will it help me study? We'll see...

Well, not only did it help me study (I only had to go over something once to comprehend it, making time spent far more efficient), writing answers on the final exam came with relative ease. I just kept flipping pages and writing and flipping and writing... I don't recall having a moment where I needed to pause for any great length in thought, except for one question where I had a proof of a mathematical theorem that just escaped me because I was getting conflicting images from another theorem's proof in my mind. Yet that accounted for ~5% of the test...and this was all accomplished in <1/2 the allotted time. Furthermore, the anxiolytic effects are amazing. I normally become gut-wrenchingly nervous before an exam, but not in this case. Sure, there was some mild concern over "what's going to be on it?" but none of that "stage fright", as it were.

I can definitively state there was synergy. Having tried all the racetams as unique inputs, then mixing them, the effect of the latter had a unique quality to it which can't be explained as a sum of parts. Oxiracetam, on its own, feels very much like Piracetam. Whereas, Prami- felt more subtle, coming on later, but lasting longer (it seemed).
Ani- by itself did not present any profound effect, but in testing the "mix" with and without it, there seemed to be a difference. When mixed, the "lengthening" seemed more apparent, but that subtle shift from the Piracetam to Prami effect wasn't noticeable when the Ani- was excluded. It's possible the effect was subjective, or a one-time acute reaction (being more cognizant of effects when not under a test condition).

For the moment, I am convinced there is merit in further study and experiment.
Onward Science!

Very interesting!

I do still take it. I take ~15mg in the morning and a little less before bed. I still notice the effects, but they are less significant because they seem to be normal. I hadn't tried any of the other kinds until two nights ago. I was camping and on a some bk 2c b, and my hiking buddy brought piracetam saying it was more instant and our vyvanse should only be used as a last resort because of dehydration. That made a lot of sense.
Thing is piracetam tastes like SHIT. Doses are high too, I believe we ate about 700-1200mg ever dose. The night I really got a pop from it, we were tripping, great night, decided to make kratom extract shots with (skittle disolved) Sailer Jerry. Then we added roughly 2200mg of piracetam(took noopept in morning), 40mg vyvanse, 1mg etizolam and 100mg bk 2c b. We were very drunk that's why, but we knew we'd be safe with that sip by sip. And we WERE! Took us all night to drink that but we slept just fine that night.
I felt like a little kid at six flags with a lolly pop. We pranced on rocks with our now established balance and smoked doobage on every cool thing we saw to look at the sky and speak metaphysically.

Last night I took a gram or so while we were drinking (I was tripping yesterday as well.) It was great! I was exhausted, after that, nope! Felt on key, in unison again.
Had a strange effect on my patterns, they'd become more veiny instead of mandlebrot systematic if that makes any sense.

Still I think I am going to buy some. And test the ones you speak of. Thanks for participating in this thread, it's a fun little science!
Have you experienced any negative effects from over-doing it? I feel.... Off.. When I take too much noopept, so I found my right dose. Also I do skip days occasionally. Maybe once a week. But it feels good when I do so. I almost feel more alert than before, leading me to believe I reached my capacity for the week and needed to give it a break.

In the past, anything above 70ug of LSD or 1gram+ high potency mushrooms (oaxaca or penis envy) would put me in an uncomfortable place. Ive been using these substances for over 3 years with a similar effect. I throroughly enjoyed near-threshold doses as anything more would turn negative. I have since been taking 30 mg Noopept and 750 mg Oxiracetam orally for 21 days. I would agree I feel subtle effects on the same day of ingestion.

I have since tried experiementing with 280 ug of LSD, assuming I was ingesting 140 ug--forgot THAT hit was stronger than the other.

I had realized what had happened about an hour after dosing but not once did I have ANY issue. I even went to Lowes to pickup hardware approximately 3 hours into my trip WITHOUT issue. I felt like I was in a movie but not once did I feel scared or out of control (unlike the last 3 years of experimentation.)

This event occured four weeks ago and I have dropped both LSD and psylocybin mushrooms in much larger quantities than I ever have with a desire to go further.

My productivity at work has increased. My self-control and ability to "not react" to (uncomfortable) situations has improved dramatically.

I would not doubt for a minute this could be placebo or simply self-growth but it has defintely helped me in some way; albiet mentally physically.

heckler73 said:

As for negative side-effects; yes, I did have one episode of a mild headache (which felt like it was in the back of my skull around the right occipital lobe). However, I suspect it was caused from over-doing the Noopept (>100mg/day easily), and as soon as I started adding the choline, not even a mild "pulse" of pain has arisen despite my "stacking".

Outside of that, I do notice a need to eat more. This stuff seems to stimulate appetite in me more so than weed. I'm not certain why that happens, yet, but there has been some research in using noopept (IIRC) with diabetes treatment. I'm not sure if they were studying blood sugar or insulin or what, but it may be related. Or maybe it's just the fact my brain is working harder now, and requires more fuel? I seem to be attracted to starchy carbs (Potatoes, Pasta, etc) when in that state.

Anyway, so far so good.

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If I take >60mg/day of Noopept, I feel like a zombie; Antisocial and demotivated.
Never experienced a headache but I put away an ounce a week + constant dabs and edibles on top of that so I rarely experience headaches. Maybe the two could be correlated? Haven't added choline yet as I haven't felt the need; although I'm aware of it's existence. Would you say it improved other aspects beyond headaches/pain?

I agree with the need to eat, but I thought that was just a personal thought considering I don't eat enough usually lol.
I'm definitely more aware at the need for nutrition, where-as normally I'd neglect it.

I similarly often feel this way dropping LSD--I like to improve myself and my homestead, research ideas, take notes, and inform other family members of health-beneficial substances I may encounter.

Scharfschutzen said:

If I take >60mg/day of Noopept, I feel like a zombie; Antisocial and demotivated.
Never experienced a headache but I put away an ounce a week + constant dabs and edibles on top of that so I rarely experience headaches. Maybe the two could be correlated? Haven't added choline yet as I haven't felt the need; although I'm aware of it's existence. Would you say it improved other aspects beyond headaches/pain?

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As a matter of fact, they are correlated. Cannabis is (ironically) considered a potential nootropic through its AChE-inhibiting properties (putting it into the same class of cholinergics as Huperzine-A and Donepezil, neither of which I have tried... what for? I smoke the herb regularly).
As for "improving other aspects", I'm not sure what you are referring to. Do you mean choline, or noopept, or...? And do you mean other effects such as social lubricant or anxiolytic? I did notice something peculiar about the piracetam and its positive effect on nail thickness. That's a weird side-effect, but it makes sense with the extra blood-flow my fingers receive. I don't know if that would happen with someone who already has healthy digital blood-flow, though.

EDIT: I see that you might be asking about choline. No, I have not noticed anything specifically in regards to that, outside of eliminating the condition that probably led to the headache. I need to run a trial of that on its own to make any determination. That's a good idea, though...

I read a tiny bit about choline when I was doing a lot of research on this. I will continue once I am less beat. Work has been killing me. Not to mention the partying.. lol

I'm interested in that ox- nootropic though. Hmm.. I'll have to do some reading around and test some things. Thanks for all the input, seriously. I don't think I've found this much info on this subject anywhere. Well with the variety of substances we are speaking of anyway.
Anyone notice the smell thing from any of these? I'll smell something and suddenly gain access to a completely forgotten memory that correlates with the smell.

Funny about the pot being a nootropic, do you have any links? I'd like to read about that. I know it eats my short-term temporarily, but I've read a little about its benefits in long-term memory storage and Alzheimers'.

Also while we're on a thread about cognitive enhancement, look into iodine supplementation.
http://articles.mercola.com/sites/articles/archive/2013/06/29/iodine-deficiency-risk.aspx

high|hgih said:

I read a tiny bit about choline when I was doing a lot of research on this. I will continue once I am less beat. Work has been killing me. Not to mention the partying.. lol

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Well, choline is a precursor to AcetylCholine (ACh), and that is important for the purposes of processing information.
Wiki is not bad for an explanation in this case;
http://en.wikipedia.org/wiki/Cholinergics

And note the reference of effect on the parasympathetic nervous system. This could explain why activities such as playing guitar become so different feeling (in my case, easier) under the effects of the -racetams.

I'm interested in that ox- nootropic though. Hmm.. I'll have to do some reading around and test some things. Thanks for all the input, seriously. I don't think I've found this much info on this subject anywhere. Well with the variety of substances we are speaking of anyway.
Anyone notice the smell thing from any of these? I'll smell something and suddenly gain access to a completely forgotten memory that correlates with the smell.

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I don't notice any memory associations to smells outside of the ordinary. It is a common trait in humans to associate smells with memories since the olfactory system is the foundation of all the senses (i.e. sight, sound, touch, taste...) being the only set of nerves wired in the same orientation as input. That is, it is hypothesized the olfactory system was the first to evolve when we were still pond slime. All the other senses cross hemispheres in the brain, but not the olfactory. The only thing I've noticed is a heightened perception of smell. Things I would not normally smell become far more pronounced.

Funny about the pot being a nootropic, do you have any links? I'd like to read about that. I know it eats my short-term temporarily, but I've read a little about its benefits in long-term memory storage and Alzheimers'.

Also while we're on a thread about cognitive enhancement, look into iodine supplementation.
http://articles.mercola.com/sites/articles/archive/2013/06/29/iodine-deficiency-risk.aspx

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Sorry, no links off hand. I just culled that info from Wiki (presuming it was reasonable based on what I know already about cannabinoid physiological effects). However, a quick google brought up this:
http://www.ncbi.nlm.nih.gov/pubmed/17140265
The connection comes from Alzheimer's research. As for iodine, I get plenty of iodized salt in my diet. I should be okay there. I believe Wendy's restaurant uses iodized salt on their fries. I just ask them for a couple extra packs of salt to use elsewhere. It's good to have around when one has the flu since a snort of saline solution clears the nasal passages like a dream.

Okay so I have a stack of noopept, choline, oxiracetam and Celastrus paniculatus (intellect tree) and it seems to be doing the perfect trick!

Every morning, even if I am deathly tired and running on no sleep, once I sit long enough after eating 6-800mg oxiracetam, 20-30mg noopept, 50mg choline and a pinch of seeds ~10, I am awake and alert. It doesn't even require a shower or movement! Of course I shower and move too, but that's after adventure time is over. Because adventure time is the bees knees with a cup of coffee and some eggs!

My dreams are vivid as ever and there seems to be a new thing to them, something will happen that is symbolic and lets me gain access to an unsorted life problem. Though this may be the cause of either lack of marijuana smoking or home-made ayahuasca trips. I also notice that I can finish my friends sentences 1000x better than before. And it surprises them every time. I know what they're going to say in an argument immediately and already have a rebuttle and find myself interrupting them. Of course our arguments aren't with anger, more like a back n forth kinda thing. Still, it surprises them. Even other people notice is my point here.

So, any of you have anything to say that's new about nootropics?

Edit: apparently my dosage of choline is lacking. So I just ordered 1,000 grams.

wow, I wonder how all of this might affect an aging drug addled mind.

I think I'll try it, if I can remember to put it on my list.

but from what I scanned, is there a memory enhancing component? I didn't see.

saw a friend become very agitated when he couldn't easily draw a particular word from memory. It occurred to me that folks who are accustomed to such failure of word recall when they are high are perhaps more comfortable with the same failure as a result of age. Losing words in the middle of a conversation even while sober long ago stopped being alarming to me.

as does incoherent rambling.

so, memory enhancements?