NirvAnamation
Well-Known Member
I've done LSD more than plenty of times, and same with shrooms. I've thought about trying both in one dose, but i heard a lot of ppl call it 'pointless'. Any thoughts?
Lucy Shroom Trip? Pointless?
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Prefontaine
Well-Known Member
LSD as an agonist and antagonist at central dopamine receptors
KERN VON HUNGEN, SIDNEY ROBERTS & DIANE F. HILL
Department of Biological Chemistry, School of Medicine and the Brain Research Institute, University of California Center for the Health Sciences, Los Angeles, California 90024
THE mechanisms involved in the psychotomimetic actions of D-lysergic acid diethylamide (D-LSD) and other hallucinogenic agents have not been defined. Neurophysiological and behavioural studies indicate that D-LSD may interact with serotonin and catecholamine receptors in the central nervous system. Thus, this drug seems to stimulate certain central serotonergic pathways1,2, while inhibiting the activation of other pathways by serotonin3,4.
KERN VON HUNGEN, SIDNEY ROBERTS & DIANE F. HILL
Department of Biological Chemistry, School of Medicine and the Brain Research Institute, University of California Center for the Health Sciences, Los Angeles, California 90024
THE mechanisms involved in the psychotomimetic actions of D-lysergic acid diethylamide (D-LSD) and other hallucinogenic agents have not been defined. Neurophysiological and behavioural studies indicate that D-LSD may interact with serotonin and catecholamine receptors in the central nervous system. Thus, this drug seems to stimulate certain central serotonergic pathways1,2, while inhibiting the activation of other pathways by serotonin3,4.
NirvAnamation
Well-Known Member
So is this a yes or no? XD i understand the chemical hooplah involved, it just doesnt really answer my question haha
Prefontaine
Well-Known Member
really they are completely different, and mixing the two may be a very bad idea, resulting in an excessively confusing experience, or you might just pass out and watch kaliedescopes for hours, I would say if you think its worth the risk and have someone to baby sit you, tell us how it goes
Ellis Dee
Active Member
Well since antagonists inhibit responses the psilocin would have a hard time pulling it together and pushing LSD off of a receptor target.
Its likely to give a light effect, that being said LSD will overpower the experience, and the psilocin will probably just breakdown over the course of the trip.
Its likely to give a light effect, that being said LSD will overpower the experience, and the psilocin will probably just breakdown over the course of the trip.
NirvAnamation
Well-Known Member
Well i've heard that either they didnt feel one or the other while doing it, some ppl say its awesome. Idk. I was going to try one L hit and 2gs of the shrooms. Thats a half dose of each (usually 2 hits of L or 3-4 gs of shrooms is a full dose for me)
LSD is a 5ht2a (reason for psychedelic effect) agonist just like Psilocin. It may have antagonist properties elsewhere, but that will NOT decrease a trip. I did 9 hits of LSD and half ounce of shrooms. Best night of my life! The shrooms actually overpowered the LSD!! I COULD NOT stop laughing. I'm happy thinking about it. I was on ANOTHER LEVEL! <33
Ellis Dee
Active Member
Sorry my data is very old.
It isn't effected by antagonists as an agonist is suspected should.
Its anyones guess which drug was stronger. If you came up on the LSD first the shrooms would have less effect because of cross tolerance and be metabolised to inactive compounds in a while. If you took the shrooms first then the LSD later the LSD would have a hard time getting on to 'used' receptors because of cross tolerance.
This kind of dosing would largely just metabolize and otherwise extend the trip.
There is such a thing as receptor saturation hadd!
It isn't effected by antagonists as an agonist is suspected should.
Its anyones guess which drug was stronger. If you came up on the LSD first the shrooms would have less effect because of cross tolerance and be metabolised to inactive compounds in a while. If you took the shrooms first then the LSD later the LSD would have a hard time getting on to 'used' receptors because of cross tolerance.
This kind of dosing would largely just metabolize and otherwise extend the trip.
There is such a thing as receptor saturation hadd!
Prefontaine
Well-Known Member
Even today the most reputable researchers admit that they only have a slight understanding of how psychedelics react in the brain, the reality is that lsd, silicin, and psilicybin are all very different chemicals that react differently in the brain, NO THEY ARE NOT GOING TO JUST CANCEL ONE OR THE OTHER OUT, and most people seem to agree that the experience is really F'ing intense, so just be careful and dont do anything stupid,
also this should not be undertaken by someone who is only expiramenting, DONT MIX THESE THINGS UNLESS YOU REALLY KNOW HOW EITHER DRUG WILL AFFECT YOU,
NirvAnamation
Well-Known Member
I've done both enough times to know how they affect me. Like i said before, im only takeing 2gs and a hit.
That's very true, but what you aren't putting together is that lsd and 5-ho-dmt are SELECTIVE 5hta receptor agonists, they hit different parts of the 5ht2a receptor which means initial full saturation doesnt occur until the psilocin or LSD is taken 2nd because they have to fill up the untouched part of the 5ht2a receptor for it to really saturate correctly.