constant air flow reduces mold, as well as the need for supplemental oxygen and co2. there is plenty of co2 and oxy in the air, but to take proper advantage of it you will need to flush the air 24/7. some of you will use powerful fans that bother neighbors or roommates, so maybe use a smaller fan if that's the prob and shit can the humidity at night mainly because of the fact that it is useless and eventually counterproductive and even distructive in the dark for this plant. but, make sure that you are getting fresh air too. don't go through the motions, step correctly and make it fresh air, as opposed to just oscillating in your habitat and recycling stale humid air. so, the answer is YES. run it at night.