how big is the room? and guru is right, this is a trick question. 2x600's are better than a 1000 (lumen wise) by only putting out 200 more watts. Again it depends on the bulb. Also plants don't use lumens like we do. What you want to look for is the correct PAR wavelength in the bulbs.
IMO if the room is wide but not that tall use the 3x400w. but if its tall and skinny use the 2x600w. They can penetrate deeper than the 400w.