uhhhh.....I think most people are going in the wrong direction.
I'd say this is from nutrient toxicity or deficiency, only you can choose which one, and the wrong solution will fuck up your plant worse.
That looks like calcium or magnesium deficiency. The rust spots are similar to Ca def because they are interveinal, but normally Ca def starts at the leaf tip and progresses back. I notice with my Mg def i get yellow interveinal chlorosis all over the leaf, maybe your is at the start.
It's hard to help you any further, because I don't know what pH your soil/mix is in (indicating nutrient availability), what you feed with, and how long the problem has been going on for.