I smoked when I had a bad stomach virus. Well, actually I used my vaporizer. I was puking everytime I got up and then when it finally started getting a little better I turned on the vape' and all was good. I only puked one more time that night (compared to the 20 or so times I did earlier) and I could actually eat since I could bring myself to eat in over a day. But if you are going to smoke I'd say just take it easy and smoke a little then sleep. If it isn't your throat thats bad then there shouldn't be much of a problem.