None imo...
Split my perp grow up one using my traditional miracle grow mix and one all organic (landrace sativas)
I have 30 something in each, my flowering room hits capacity around 70, so this isn't just one plant against another side by side....
My mg regimen is bloom booster(has good ratios for veg too, I use it throughout the life cycle) a touch of epson salt for the nutes..the medium is 50:50 African violet and perlite with a bit of lime(mainly for Cal)
My organic...not the best, wasn't gonna throw a bunch of money on something I will run once..ended up running it a few times to "dial" so it would be a fair evaluation
Its also 50:50 perlite but with an organic dirt mix from my local garden shop..added some green sand and bone meal, no lime this time not needed..and fed with teas as needed (rarely)
I realize I could have made a better organic mix...but it was all organic.. I noticed differences yes..for some reason they didn't like to droop with underwatering and couldn't use that as a sign of when to water..I can't pick up many of my plants so I use their drooping as a marker and mark the time it took....obviously I take into account the reduced uptake later in flower etc..
Anyway I'm rambling a bit......but i also noticed the taste was the same, the plants didn't seem any different structure/growth wise..nearly identical in everway except the root zone...as mentioned..they could handle over and underwatering much better (and I had to be careful with that) they also were less prone to orange perlite/ mildew and algea growth
Potency and flavor remained the same in my trials as did density and structure...I still have some in organic waiting to chop then its back to miracle grow for me...I am biased towards miracle grow as I've been using just over a decade.....so take this with a grain of salt I suppose....my wife couldn't tell a difference between buds though