when your main buds are ready you can pick them and leave the smaller ones to mature. get a magnifying glass or a eye peice out of a telescope or a microscope. somethin to see really close. look at the trichs. if they are transparent(clear) they are premature. if they are milky your close. you want half milky and half amber color. that is when it is at its peak and is most potent. plus if you harvest early you loose yeild. dont forget to flush b4 harvest