Generally, the genetics won't change. But, if you don't take decent care of the mother plant then the potential is there for the genetics to change/drift with enough time. I have seen it happen, a mother was kept for 2 years and this newer grower always put the healthiest cuttings into flower and kept the weak ones for new mothers. Eventually, some of the plants started to hermie even though conditions were exactly the same. Also, if you take the cuttings from younger, healthier, faster growing parts of the plant you shouldn't have much problem. It will take time for any issues to develop, if they are going to, so you shouldn't worry about it too much.
