Here for a friend who is considering acid, but she's on antidepressants

So I did my own googling and found out they actually did research studies on this. Apparently it depends on how the antidepressant works, but it can either increase the effects or decrease depending on the antidepressant. According to the research studies (I'll have to go diving again to find them if ya'll are so inclined to read them) hers will decrease the effects. I'm just popping up here to see if any of ya'll have the same situation or know someone in the same situation. She has smoked Mary J and had no problems, she also smokes cigs. Secondary question, for those of you who do/know someone who does trip on antidepressants, have you/they smoked (Mary J or cigs) while tripping? I read that the antidepressant can effect blood circulation (true?) and from experience I know that trips can make things pretty exciting so I was worried about a synergy of increased heart rate effects. Though that is just me doing pseudoscience and theorizing worse case scenarios.

I've tripped while taking SSRI antidepressants MANY times. You need to take more is all. I'm not sure how much more though. I used to take like 5-10 as my average dose (regardless of being on an SSRI or not) but I wouldn't suggest that to a first timer. And I smoked both pot and cigarettes pretty much every time I've ever tripped.

Only one way to find out right!

Depends on which.

If it's a modern SSRI (or the many derivs), then as the duck said, you may need an increase in dosage.

But: If it is one of the "older" ones, it may be an MAO inhibitor(elavil rings a bell), which in turn may mean you'd need less of a dose (not really sure, I know you'd need less for shrooms, but acid? Dunno, needs a bit more googling).

Does your friend have to restrict her diet becuase of her meds? If so, most likely MAO inhibitor.

MAOIs greatly potentiate psychedelic drugs, but are rarely used these days due to all of the interactions. I would advise against taking psychedelic drugs on them at all. Consider that things like harmala alkaloids and Syrian rue alkaloids are much weaker inhibitors of MAO and look at what they do. I've heard 20ug of LSD is pretty crazy if you're on Parnate.