sealing it off wont work, if you do seal it off your gonna draw negative pressure in the room and your furnace needs fresh air... I used to do hvac. if your gonna seal it off your gonna have to add a fresh air intake. usually some three inch pvc plumbed out the side of your house with a 90 on it is what you will use. pipe size is dependent on how far your running it amd how many bends are in the pipe. the furnace should have an intake somewhere on it for this exact reason. the other thing you could do if you shell out the big money is put a hepa filter on your return it will cycle the air pryor to being re distributed throughout the house. the reason it stinks is your drawing air that stinks lol put a carbon filter in your grow area if you already do add another if that area doesnt stink then your air wont stink. or you could seal your grow completely off, just not your furnace. hope that helps