Yes it is safe and totally unnecessary. You can clone in a glass of tap water. But I have used the gel. One, it has a shelf life once opened. It helps to refrigerate it but that simply delays its viability a little. A better choice next time is cheap cloning powder. Either way they contain butyric acid or a related compound so six of one and half a dozen of the other.
The cloning aids I have seen/used are all intended for use on woody plants like trees and berry canes. Pot qualifies for that.