perty much what ronjohn said
It's all fiction. It's an exaggeration of a real world event that did happen (I don't doubt they tripped a day or so, did a lot of coke, and smoked a lot of weed, but the rest has to be fiction). If you tried to tripped on LSD, mushrooms, or mescaline in one weekend you'd only be able to trip just once. These drugs are all very similar in terms of chemical makeup and the way they work in the body. They also aren't that toxic so your body builds up an immunity to them real fucking fast (one aspirin is more toxic than a mushroom dose).
Seriously try to trip twice in one week and see what happens...I've done it and I know for a fact for the second trip you need a fuck load more shroom/LSD than you would need for the first trip. If you wanted to trip more than once in a week then you'd need to low dose it on one trip and do a hella high dose on the second. Thats what I've noticed at least. Even tripping twice in one month can lead to so some weak ass trips.
Got to pay your dues if you wanna sing the blues,
And you know it don't come easy.
perty much what ronjohn said
lifes a one way path, but try going off road and eat the mushroom then you'll understand were your path will lead
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