JWH-018 Synth here!!!!!!!

MrEDuck

MrEDuck

Well-Known Member
Knowledge of chemistry doesn't mean one has a knowledge of botany.
Well to disprove your synth I need to know what "nafindola" is supposed to be. See it only happens to show up in posts claiming a JWH synth on forums or sites that make no sense. Sigma doesn't list it, nor does any other legit chemical supply house (the places real researchers buy their chemicals). I'll draw up the full real synth in different colors and go through the retrosynthesis to explain why it's the actual synth. But it's going to have to wait for me to take the time to do it, it should be done tomorrow or Sunday as I'm going to have to go to the library to UL. Please provide the structure of this 1-nafindola or something demonstrating it even exists.
 
Mental91

Mental91

Active Member
Recipe for the synthesis of JWH 018 is not complicated, follow the instructions and keep the proportions (per 1 nafindola, 0,2 sodium hydride, 0.76 amyl) finally get a quality product. In this manual we describe how to get JWH-018 in the form of oil, its difference from the powder only in the fact that the powder is more convenient for transportation and storage, but otherwise "tactical and technical characteristics are identical. Hold on I'm gonna post manual. So you don't know what 1 nafindola is and your a chem expert? LOL Yea you don't shit
 
MrEDuck

MrEDuck

Well-Known Member
If it exists then post it's structure to prove me wrong. Shouldn't be hard if it exists. Fuck even the CAS# will do. You don't seem to understand you can't do this as a one pot reaction.
 
Mental91

Mental91

Active Member
MrEDuck said:
If it exists then post it's structure to prove me wrong. Shouldn't be hard if it exists. Fuck even the CAS# will do. You don't seem to understand you can't do this as a one pot reaction.
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That's odd because if you REALLY read what Huffman said he said it's one of the easies synths known to man. It can be done in one pot seeing as your mixing 2 chems and throwing in one more. I'll give you till Sunday. I'm done proving myself now it's your turn.
 
forgetfulpenguin

forgetfulpenguin

Active Member
For sake of keeping people safe I'm just going to go ahead and post a real synthesis that was reported and tested by real bees in a proper hive. My apologies to the hive but fake info like what the OP is spreading is dangerous and needs to be shutdown.

pyramid said:
Here is an example of alkylation to JWH-018, 1-pentyl-3-(1-naphthoyl)indole, MW 341.4

To a 250ml 3 neck RBF fitted with thermometer, condenser and a stir bar there is added 3-(1-naphthoyl)indole (3g, 11mmol) followed by dry DMF 50ml. Potassium hydroxide flakes (1.5g, 27.5mmol 1.5eq.) were added in one portion and the setup purged with butane. The flask was heated to 60-70 degrees C on a water bath for 20 minutes with stirring. A green solution with ppt is obtained. After this time, 1-bromopentane (4.3g, 28.6mmol) was added in one portion via glass syringe. There is an immediate color change to red and the flask is heated at an internal temp of 60-65 C for 3 hours. KBr ppts in the first few minutes after addition of the alkyl halide. It is then cooled to RT and diluted with 150ml H2O, and extracted with DCM 3x 40ml. The organics are washed with water 3 times then the solvent is evaporated. There is excess bromopentane as noticed by the smell so it is removed under vacuum in a hot water bath. 3g of amber oil was obtained (8.8mmol, 80% yield) The amber oil that remains is the product. It is a pain to get it to crystallize. Only after 1 month in the refrigerator did crystals begin to form. By covering them with a small amount of IPA cleaned them up and caused all of the oil to crystallize. Once you have a seed crystal the oil can be directly crystallized after alkylation, but I have had no luck getting it to crystallize right after without the seed or with ethanol. The obtained material is completely melted by 61 C, lit Mp is 60-62 C.

The product is fucking active and is obtained as beige to yellow slightly gummy crystals. It would be best to straight chromotograph the oil but not everyone can do that. :P

Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR.
“3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor”.
Bioorg Med Chem. 2003 Feb 22;11(4):539-49.
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meme said:
Shouldn't alkylation be done first? If only to eliminate the (mildly) acid pyrrole nitrogen from the Grignard? While it is not needed (indole grignards are routine chemistry), is there any advantage to doing that step last?

Also, all of the JWH compounds that the DEA has issued intent to control contain the napthoyl moiety, perhaps that would be best to "leave off." The naphthoyl group can be replaced with a LARGE variety of functionals, much more than the 1-position of the indole can withstand and retain psycho-activity.
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pyramid said:
I do not know how it would effect the reaction by alkylating first, but the main reason for making the naphthoyl indole first was it opens up a few compounds that can be made directly from it. Now of course if alkylation first resulted in the product we want then I'd probably want to do it first, and this would not make a difference in the order of alkylation. It is worth a shot though, however I won't be attempting that soon.

Yes indeed most of these compounds are scheduled or soon will be so analogs containing other groups would be an excellent thing to research. A wide variety of analogs can be made with alkoxy-naphthoyl chlorides and finding synthesis options for many of the starting acids would be useful. What ideas do you have for replacement of the naphthoyl? I'm not super knowledgable in pharmacology affecting groups so not sure what to start thinking of in that regard. Keep in mind, this is purely at home chemical curiosity for me and I do not have EXTENSIVE knowledge yet.
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meme said:
2-substituted phenylacetic acid compounds seem quite worthwhile (i.e. JWH 250).

Anthracene is another homolog of naphthalene which fits into this discussion.
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pyramid said:
250 is definitely on my to do list. I'M also thinking of 4-methoxybenzoyl chloride, which following the same steps would give RCS-4. Am I right in assuming 4-methoxybenzoic acid can be simply turned into the acid chloride with the usual method? Then the main issue is acquiring the acids, but its not too hard.
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Intergalactic Captain said:
A thread was posted under my SN on SMDB a year or two ago regarding a couple of potential ideas - Which were, for the most part, seen as either unfeasible or stupidly circuitous. The concensus, IIRC, was that huffmann's original and later routes were the quickest, cleanest, and cheapest; alkylate indole, then react with the naphthoyl (or whatever) chloride; indole + acid chloride, then alkylate...

3 reagents, 2 synthetic steps - How could it be easier? Well, try aquiring indole, napthoyl chloride, phenylacetyl chloride (substituted, etc), napthoylindole, etc... Or any common acid a-halogenation reagents for that matter, in quantities over 1-5 grams, as an individual... The quantity qualifier is important, as these reagents CAN be found, but at one hell of a "price of convenience" premium. Alkyl halides are a piece of cake, provided you can find the parent alcohol (and don't bother looking for n-pentanol or n-pentyl esters - Unless you get a COA, you've probably got iso or sec-amyl... I've found one source, expensive, but it's a cornucopia that doesn't operate on the quasi-legal side of the fence...Not gonna mass-publicize them)...

The goal here should be finding a way to AVOID huffman's routes - They're nothing special, nothing novel, just sophomore-level o-chem hoisted to infamy for the end result. Given an academic lab, anyone could do it - However, without that type of stockroom, where are we left?

...In summation, here's an idea, or a few that I've been tossing around... Phenylacetic halides are ripe for exploration and "relative" ease of preparation... Many substitution patterns are readily availabe as their benzaldehydes, acetophenones, and benzoic acids - These are all simple starting blocks for homologation to the phenylacetic acids and, (the caveat), the phenacyl halides... A few reactions to look up - Stephen reduction, and (Don't think there's a name for it, but it's patented) and one-pot from a benzoic acid to a benzonitrile via NaHSO4/Urea/Sulfamic Acid ... And the reaction of a benzyl halide with a cyanide... And probably countless others...

So, long story short, we should be focusing on the precursors (as it used to be?)... Short and sweet (minus the chromatographic separation), but that's only when one has the napthoyl or phenacyl halide - Perhaps those interested should be focusing instead on the preparation of acid-halide reagents, or a new route altogether (and forget grignards - I haven't explored EVERYTHING, but that nitrogen, alkylated or not, seems to fuck with just about any grignard or grignard-style organometalic couplings)...
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Mental91

Mental91

Active Member
Here is an example of alkylation to JWH-018, 1-pentyl-3-(1-naphthoyl)indole, MW 341.4

To a 250ml 3 neck RBF fitted with thermometer, condenser and a stir bar there is added 3-(1-naphthoyl)indole (3g, 11mmol) followed by dry DMF 50ml. Potassium hydroxide flakes (1.5g, 27.5mmol 1.5eq.) were added in one portion and the setup purged with butane. The flask was heated to 60-70 degrees C on a water bath for 20 minutes with stirring. A green solution with ppt is obtained. After this time, 1-bromopentane (4.3g, 28.6mmol) was added in one portion via glass syringe. There is an immediate color change to red and the flask is heated at an internal temp of 60-65 C for 3 hours. KBr ppts in the first few minutes after addition of the alkyl halide. It is then cooled to RT and diluted with 150ml H2O, and extracted with DCM 3x 40ml. The organics are washed with water 3 times then the solvent is evaporated. There is excess bromopentane as noticed by the smell so it is removed under vacuum in a hot water bath. 3g of amber oil was obtained (8.8mmol, 80% yield) The amber oil that remains is the product. It is a pain to get it to crystallize. Only after 1 month in the refrigerator did crystals begin to form. By covering them with a small amount of IPA cleaned them up and caused all of the oil to crystallize. Once you have a seed crystal the oil can be directly crystallized after alkylation, but I have had no luck getting it to crystallize right after without the seed or with ethanol. The obtained material is completely melted by 61 C, lit Mp is 60-62 C.

The product is fucking active and is obtained as beige to yellow slightly gummy crystals. It would be best to straight chromotograph the oil but not everyone can do that. :P

Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR.
“3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor”.
Bioorg Med Chem. 2003 Feb 22;11(4):539-49.

That may have been the way he made it but there is alot of different ways to make the same chemical. That's like saying there's only one synth for meth... BTW what did I get sold then? I would really like to patent and sell it.
 
C

claytonwiskur

Member
Mental91 said:
So here it is people! I gave a chemist 500 bucks to find this for me and he did. It's extremely easy! Good luck getting chems to make it though. Remember you heard it from me first!

So, in a dry flask 6A, equipped with a reflux condenser are placed 20 g of sodium hydride, poured 100 ml of dry DMSO, stirred, added in small portions (5-10g, and the mixture is heating, cooling should be good) 100g 1-nafindola periodically stirred at room temperature, 30 min. Then add 77g of n-pentilbromida (amyl methyl). The reaction mixture was incubated at 65 gr. Celsius 3 h on an electric hot plate with periodic stirring. PRODUCT fall as oil! The reaction mixture was washed 3 times with water in 5-fold volume.

Attention! Sodium hydride ignites on contact with water! Be careful when working with him!


Solvents:
The product is highly soluble at 35 grams. C in diethyl ether and isopropyl alcohol, worse than in ethanol.
Do a better job with the ether, maybe, he flies at room temperature and the basis for faster drying!
The water insoluble product!
Applied in concentrations from 0,5 to 2g per 10 g basis, depending on the desired effect.

** How to wash?


To wash pour into a beaker (1L) 200ml oil and add water, mix thoroughly and allow the oil to settle, then drain. Repeat 5 times until the water is clear.

** For those who do not want to bother with flushing questions

The reaction mixture was flooded with water at 5 times the volume and mix, then poured 200 ml of ether, stirred and made to stand. The reaction mixture was divided into 2 layers (high - oil in the air, the bottom - the water with impurities). Collected the top layer. If necessary (if the previous operation to select all the oil could not) add another 200 ml ether, stirred and give stand, then collected and combined with previously collected. All product is ready for further action!
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so i take it u must smoke spice.. that's the fake weed.... it's undectable in drug test's exc.
 
forgetfulpenguin

forgetfulpenguin

Active Member
Mental91 said:
That may have been the way he made it but there is alot of different ways to make the same chemical.
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Irrelevant seeing as the procedure you posted uses 1-nafindola which isn't even a real chemical (should have claimed you used ground up unicorn balls at least that would have been funny) and you claimed it isn't even supposed to be a synthesis for JWH-018. Just because there are multiple routs to the same chemical doesn't mean your bullshit is anything but.

You also have yet to answer any of question posted about your "procedure."
 
Mental91

Mental91

Active Member
forgetfulpenguin said:
Irrelevant seeing as the procedure you posted uses 1-nafindola which isn't even a real chemical (should have claimed you used ground up unicorn balls at least that would have been funny) and you claimed it isn't even supposed to be a synthesis for JWH-018. Just because there are multiple routs to the same chemical doesn't mean your bullshit is anything but.

You also have yet to answer any of question posted about your "procedure."
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IDK What to say about it it works. What else does it matter if dosage and high are the same?
 
forgetfulpenguin

forgetfulpenguin

Active Member
Mental91 said:
IDK What to say about it it works. What else does it matter if dosage and high are the same?
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You are telling people to use at least one chemical that is not real. Even if you are somehow, with some mislabeled chemical that you are simply too ignorant to identify, getting results no person on this planet can reproduce it with the information you have provided.

Try this, replace the 1-nafindola part with "ground up unicorn testicles" and ask yourself how you are going to try it seeing as there is no such thing as a unicorn. Can you see the problem now?
 
Mental91

Mental91

Active Member
I'm talking to the guy on FB right now. He said 1-pentyl-3-(1-naphthoyl)indole is jwh-018 or AM-678. 1-nafindola is an abbreviation they use in Russia for (1-naphthoyl)indole. He said your reading it wrong because 3-(1-naphthoyl)indole means 3g's of (1-naphthoyl)indole. "When mixing chems that I provided to you regardless of what you are creating 1-pentyl-3-(1-naphthoyl)indole"
 
forgetfulpenguin

forgetfulpenguin

Active Member
Mental91 said:
I'm talking to the guy on FB right now. He said 1-pentyl-3-(1-naphthoyl)indole is jwh-018 or AM-678. 1-nafindola is an abbreviation they use in Russia for (1-naphthoyl)indole. He said your reading it wrong because 3-(1-naphthoyl)indole means 3g's of (1-naphthoyl)indole. "When mixing chems that I provided to you regardless of what you are creating 1-pentyl-3-(1-naphthoyl)indole"
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First it was JWH-018 then it was JWH-011 now it's JWH-018 again. Contradict yourself anymore and you'll give the bible a run for it's money.

There is also no point in arguing with you since you are nothing but a drug cook who can only blindly mix. People like you are why street drugs are unsafe.
 
Mental91

Mental91

Active Member
forgetfulpenguin said:
First it was JWH-018 then it was JWH-011 now it's JWH-018 again. Contradict yourself anymore and you'll give the bible a run for it's money.

There is also no point in arguing with you since you are nothing but a drug cook who can only blindly mix. People like you are why street drugs are unsafe.
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Like your so damn legal and safe. I'm sure you have your share of shit that goes around besides pot.
 
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