CBD protects against BSE/Prion diseases

Chester da Horse said:

Y'all scared about mad cow disease / new variant Creutzfeldt Jacob Disease from blood and bone soil amendment?

'Nonpsychoactive Cannabidiol Prevents Prion Accumulation and Protects Neurons against Prion Toxicity'
Dirikoc S et al (2007), http://www.jneurosci.org/content/27/36/9537.full.pdf

@greasemonkeymann

PS: Im technically hindu so I dun eat beef anyway.

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greasemonkeymann said:

damn dude, that's some seriously interesting shit right there.
So in theory.. a BROAD theory... smoking pot may help keep away altzheimer huh..
In theory as they are only suspecting that they are related...
Very good find though....
I like me a good burger man... I got a real soft spot for a well made burger...

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heckler73 said:

I believe Alzheimer's is different from CJD, or are they not?

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Chester da Horse said:

the end point changes in both diseases are accumulation of various protein aggregates that destroy the fine matrix of the brain. The precise relationship between the aggregates and the functional loss is not fully understood in either. Risk factors and possible etiological agents have been identified but I think 'Alzheimer's disease' is quite a heterogeneous group of pathologies lumped together because we lack a full understanding of what is going on.

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heckler73 said:

But did you note the different effects of THC and CBD? CBD hits the Chandler murine strain of scrapie, while THC went after the "natural" sheep scrapie.

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Chester da Horse said:

Well the murine scrapie model was assayed in neuroblastoma (cancerous) cells and the native scrapie assayed in epithelial cells. Dunno if that was a confounder.

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