I would read the ingredient list of your nutrients. Since you're apparently growing hydroponically then you must provide
all nutrients, including micronutrients. And those are very difficult to measure, quantify, and if necessary rectify. For instance, cupping leaves may be a sign of molybdenum deficiency. I've found a LOT of good, hard scientific information just using Google. For instance, you could put in the search bar something like "malformed leaves, yellow circle, hole, hydroponic growing medium, plant" and you could garner some very interesting results.
malformed leaves, yellow circle, hole, hydroponic growing medium, plant - Google Search