Could be a combination of two things lack of nitrogen and it's moving it to new growth just because your in flower doesn't mean you don't need it, you just need less of it. Check the NPK readings.
Secondly it's not getting the light needed happens to alot of lower older leaves the no longer see substantial light.
Up your base nutes slightly see if it solves the issues. Watch for burn. Increase 0.1/2 ml a time. If your struggling with EC/PPM final figures drop the carboload dose slightly, or dilute with water 1/2ltr a time.
That said you could have lock out check your pH's.