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Norfloxacin *
Application:

Infections caused by pathogens sensitive to norfloxacin:

inside - acute and chronic urinary tract infections (including pyelonephritis, cystitis, urethritis), infections of genital organs (including prostatitis, cervicitis, endometritis), uncomplicated gonorrhea, gastrointestinal tract (including salmonellosis, shigellosis ), prevention of infections in patients with granulocytopenia;

locally - otitis externa, acute and exacerbation of chronic otitis media, infection of eyes, including conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcers, blepharitis, blefarokonyunktivit.

Contraindications:

Hypersensitivity (including history), tendinitis or tendon rupture associated with taking norfloxacin or other drugs from the group of quinolones, lack of glucose-6-phosphate dehydrogenase, childhood and adolescence to 18 years for a drop - up to 12 years (safety and efficacy of norfloxacin in children and adolescents are not defined, it should be borne in mind that norfloxacin causes arthropathy in immature animals).

Restrictions apply to:

Atherosclerosis of cerebral vessels, stroke, epilepsy and convulsions, myastenia gravis, renal / hepatic failure.

Application of pregnancy and breastfeeding:

When pregnancy is possible if the expected effect of therapy in the mother outweighs the potential risk to the fetus (adequate and well-controlled studies safety of norfloxacin in pregnant women has not carried out, including for local application in the form of droplets).

Category effects on the fetus by FDA - C.

Is not known whether norfloxacin in human breast milk. After receiving the nursing mothers of norfloxacin in lower doses (200 mg) inside it was not detected in breast milk. Note, however, that other quinolone derivatives systemic action passes into breast milk and there is a potential risk of serious adverse reactions in children who are breastfed. Lactating women should either stop breastfeeding or taking norfloxacin (given the importance of medication to the mother), including for local action in the form of droplets.

Side effects:

Systemic effects

From the digestive tract: decreased appetite, nausea, vomiting, bitter taste in the mouth (including after instillation into the eyes), abdominal pain, diarrhea, elevated liver transaminases, alkaline phosphatase, LDH, pseudomembranous colitis (with prolonged use).

With the genitourinary system: crystalluria, glomerulonephritis, dysuria, polyuria, albuminuria, hypercreatininemia, urethral bleeding.

The nervous system and sensory organs: headache, dizziness, insomnia, hallucinations, fainting.

With the cardiovascular system and blood (hematopoiesis, hemostasis): tachycardia, cardiac arrhythmias, decreased blood pressure, vasculitis, leukopenia, eosinophilia, decrease in hematocrit.

From the locomotor system: tendinitis, tendon rupture, arthralgia.

Allergic reactions: itching, hives, swelling, Stevens - Johnson.

Other: candidiasis.

When instilled in the eye: blurred vision, burning and pain in the eye, conjunctival hyperemia, chemosis, photophobia, allergic reactions.