I would have to say this is really based on your experience with growing. If you've never made a hydro system before or maintained one, it can be a disaster going full scale right away. Be sure to grow in a method your are comfortable with when going big.
That being said, I have a similiar room in my basement that I've designed many different systems for. After reviewing all my ideas and picking the cheapest and easiest system to work with in this area, I would use two 4x4 foot flood tables and make a SOG ebb n flow setup.